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The other possibility that few want to talk about is ADE, antibody-dependent enhancement (ADE). ADE is a slim possibility, but it would be devastating if it is

The other possibility that few want to talk about is ADE, antibody-dependent enhancement (ADE). ADE is a slim possibility, but it would be devastating if it is. Basically it's when the virus uses white blood cells, which are supposed to kill it, to replicate. HIV and Dengue uses ADE. MERS (a coronavirus) doesn't appear to use ADE, but the jury is out on SARS (another coronavirus). It means that you can get reinfected and a vaccine is near impossible. We won't know about ADE because of the strict lockdown conditions that are still going on in China. If we start seeing more and more reinfections when things are relaxed, then we're in trouble.

narrator 7y ago
Peer reviewed citation for the above: https://www.sciencedirect.com/science/article/pii/S0006291X14013321 https://www.sciencedirect.com/science/article/pii/S0006291X1... "We also generated monoclonal antibodies against SARS-CoV spike proteins and observed that most of them promoted SARS-CoV infection. Combined, our results suggest that antibodies against SARS-CoV spike proteins may trigger ADE effects. The data raise new questions regarding a potential SARS-CoV vaccine, while shedding light on mechanisms involved in SARS pathogenesis."