4 ms·

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

37 points by lawrenceyan 7y ago

hsnewman 7y ago
I've been wondering if an antiviral will help in this.
neuronexmachina 7y ago
Looks like the NIH started a clinical trial of it as a potential treatment for COVID-19 a couple weeks ago: https://www.nih.gov/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins https://www.nih.gov/news-events/news-releases/nih-clinical-t... There's also ongoing clinical trials of the drug in China.
throwaway5752 7y ago
Anyone with actual knowledge know the state of ACE2 inhibitor and chloroquinine efficacy?
- Alex3917 7y ago
  No actual knowledge, but apparently the way Coronaviruses kill your lung cells is by inhibiting their ACE2 receptors, so I doubt taking an additional ACE2 inhibitor would be helpful. C.f.: https://www.stephenharrodbuhner.com/wp-content/uploads/2020/03/coronavirus.txt.pdf https://www.stephenharrodbuhner.com/wp-content/uploads/2020/...
  - WMCRUN 7y ago
    https://www.instagram.com/tv/B9nlVtHgGE0/?igshid=lxc09jpkk969 https://www.instagram.com/tv/B9nlVtHgGE0/?igshid=lxc09jpkk96... Second part of this video is a helpful explanation of how it attacks.
  - dogma1138 7y ago
    Coronavirus destroys the ACE2 receptors as well as well kills the cell. If you have an ACE2 receptor inhibitors that do not damage the cell it would be quite helpful as they would prevent infection while only temporarily disrupting RAS function. P.S. stephen harrod buhner is a herbal “medicine” quack so stop posting his nonsense. I swear contagion should win an Oscar for being dead on the money. Preferably a new category “called it”.
    - Alex3917 7y ago
      > P.S. stephen harrod buhner is a herbal “medicine” quack so stop posting his nonsense. Do you have any criticisms of the actual PDF I posted?
      - dogma1138 7y ago
        You mean besides the fact that they recommend taking herbs and hoping for the best? Ironically they recommend ACE2 inhibitors which was one of the primary treatment protocols explored with SARD just form unproven herbal “remedies”.
- anonuser123456 7y ago
  Well, the Chinese claim chloroquine is effective in domestic RCT. And since China seems to be light years ahead of CDC/FDA, I'm inclined to believe them.
  - fourstar 7y ago
    What a dangerous line of thinking you have.
    - anonuser123456 7y ago
      I can't tell. Is this /s? Why should I distrust an Chinese RCT over an RCT the US hasn't even bothered to consider?
- taw16092019 7y ago
  https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa237/5801998 https://academic.oup.com/cid/advance-article/doi/10.1093/cid...
- devy 7y ago
  Here is a paper from clinicians: "Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies." What China did there was they spent huge effort to find possible cures from existing drugs in the entire drug database known to mankind, herbal medicines included. Safety is kind of validated because it's known drug, the dosage might be different but I am sure some were tested with high dosages too. https://www.ncbi.nlm.nih.gov/pubmed/32074550 https://www.ncbi.nlm.nih.gov/pubmed/32074550
svara 7y ago
The title is shortened in a somewhat misleading way, making it sound at if this might be about a clinical study. The full title is: "Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease." What this is is a study performed in mice, trying to work out the mechanism of action of Remdesivir, which is known to inhibit SARS-CoV-2 in vitro. What's going to be really interesting is what comes out of ongoing clinical studies: https://www.gilead.com/purpose/advancing-global-health/covid-19 https://www.gilead.com/purpose/advancing-global-health/covid...
asah 7y ago
2018 ?
mratsim 7y ago
I would have liked (2018) in the title since it's an article from March 2018. At first glance I interpreted that it was directly tested on the current strain.
- xiphias2 7y ago
  I flagged it because I was happy and thought it's the result of the new trial that supposed to come out in a few weeks. I'm disappointed now :(
  - darau1 7y ago
    OOC, what does flagging do exactly? What does a flag mean here?
    - xiphias2 7y ago
      I think it's a signal for the moderators to take some action about the article. If many people flag it, they take it down or modify it.
- floatingatoll 7y ago
  You can email the mods using the footer Contact link to fix the year and they'll do so. (I emailed them this time.)
cknoxrun 7y ago
A lot more info and molecular/target details about Remdesivir available here: https://www.drugbank.ca/drugs/DB14761 https://www.drugbank.ca/drugs/DB14761 (full disclosure this is my site).
deleted 7y ago
[deleted]

37 points by lawrenceyan 7y ago

I've been wondering if an antiviral will help in this.

Looks like the NIH started a clinical trial of it as a potential treatment for COVID-19 a couple weeks ago: https://www.nih.gov/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins https://www.nih.gov/news-events/news-releases/nih-clinical-t... There's also ongoing clinical trials of the drug in China.

throwaway5752 7y ago

Anyone with actual knowledge know the state of ACE2 inhibitor and chloroquinine efficacy?

Alex3917 7y ago
No actual knowledge, but apparently the way Coronaviruses kill your lung cells is by inhibiting their ACE2 receptors, so I doubt taking an additional ACE2 inhibitor would be helpful. C.f.: https://www.stephenharrodbuhner.com/wp-content/uploads/2020/03/coronavirus.txt.pdf https://www.stephenharrodbuhner.com/wp-content/uploads/2020/...
- WMCRUN 7y ago
  https://www.instagram.com/tv/B9nlVtHgGE0/?igshid=lxc09jpkk969 https://www.instagram.com/tv/B9nlVtHgGE0/?igshid=lxc09jpkk96... Second part of this video is a helpful explanation of how it attacks.
- dogma1138 7y ago
  Coronavirus destroys the ACE2 receptors as well as well kills the cell. If you have an ACE2 receptor inhibitors that do not damage the cell it would be quite helpful as they would prevent infection while only temporarily disrupting RAS function. P.S. stephen harrod buhner is a herbal “medicine” quack so stop posting his nonsense. I swear contagion should win an Oscar for being dead on the money. Preferably a new category “called it”.
  - Alex3917 7y ago
    > P.S. stephen harrod buhner is a herbal “medicine” quack so stop posting his nonsense. Do you have any criticisms of the actual PDF I posted?
    - dogma1138 7y ago
      You mean besides the fact that they recommend taking herbs and hoping for the best? Ironically they recommend ACE2 inhibitors which was one of the primary treatment protocols explored with SARD just form unproven herbal “remedies”.
anonuser123456 7y ago
Well, the Chinese claim chloroquine is effective in domestic RCT. And since China seems to be light years ahead of CDC/FDA, I'm inclined to believe them.
- fourstar 7y ago
  What a dangerous line of thinking you have.
  - anonuser123456 7y ago
    I can't tell. Is this /s? Why should I distrust an Chinese RCT over an RCT the US hasn't even bothered to consider?
taw16092019 7y ago
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa237/5801998 https://academic.oup.com/cid/advance-article/doi/10.1093/cid...
devy 7y ago
Here is a paper from clinicians: "Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies." What China did there was they spent huge effort to find possible cures from existing drugs in the entire drug database known to mankind, herbal medicines included. Safety is kind of validated because it's known drug, the dosage might be different but I am sure some were tested with high dosages too. https://www.ncbi.nlm.nih.gov/pubmed/32074550 https://www.ncbi.nlm.nih.gov/pubmed/32074550

svara 7y ago

The title is shortened in a somewhat misleading way, making it sound at if this might be about a clinical study. The full title is: "Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease." What this is is a study performed in mice, trying to work out the mechanism of action of Remdesivir, which is known to inhibit SARS-CoV-2 in vitro. What's going to be really interesting is what comes out of ongoing clinical studies: https://www.gilead.com/purpose/advancing-global-health/covid-19 https://www.gilead.com/purpose/advancing-global-health/covid...

asah 7y ago

2018 ?

mratsim 7y ago

I would have liked (2018) in the title since it's an article from March 2018. At first glance I interpreted that it was directly tested on the current strain.

xiphias2 7y ago
I flagged it because I was happy and thought it's the result of the new trial that supposed to come out in a few weeks. I'm disappointed now :(
- darau1 7y ago
  OOC, what does flagging do exactly? What does a flag mean here?
  - xiphias2 7y ago
    I think it's a signal for the moderators to take some action about the article. If many people flag it, they take it down or modify it.
floatingatoll 7y ago
You can email the mods using the footer Contact link to fix the year and they'll do so. (I emailed them this time.)

cknoxrun 7y ago

A lot more info and molecular/target details about Remdesivir available here: https://www.drugbank.ca/drugs/DB14761 https://www.drugbank.ca/drugs/DB14761 (full disclosure this is my site).

deleted 7y ago

[deleted]