To answer that question one has to examine the culture of the smaller organization in contrast to the larger. If you're working at a small startup with an us vs

To answer that question one has to examine the culture of the smaller organization in contrast to the larger. If you're working at a small startup with an us vs. them mentality and you thrive there, odds are you will not enjoy transitioning into a job where you're required to submit reams of paperwork to HR, get an ID badge, interface with an incompetent mid-level manager who has to report to a boss who reports to a boss who reports ..., attend endless meetings about future meetings, socio-political silos, mind-crushing reviews, pep rallies, ominous rumors of layoffs, social embarrassment, an influx of marginally-skilled and unmotivated coworkers, offshore IT, business casual dress, the realization that all your efforts at the startup went to line the pockets of the founders who vacation ad nauseam while you continue to toil away on a dying project with increased responsibilities for similar pay while your new management makes every effort to erase your contributions while simultaneously reminding you that they bought you, albeit by directive and with corporate cash, then it is quite possible that every cell in your body rejects your new corporate overlords. However, if you're the kind of person who enjoys an anonymous routine backed by a well-known entity, then by all means, focus your attitude and culture into one of eventual assimilation, making friends and cutting deals along the way, so that when the eventual day comes, you'll be in a position to personally benefit from the acquisition by either cultural similarities or the desire to willfully carry out the bidding of your new masters.