One thing on which I have never gotten clarification, only evasion, is ... what if you are faced with something permanent that is a bummer, major, and that affe

One thing on which I have never gotten clarification, only evasion, is ... what if you are faced with something permanent that is a bummer, major, and that affects your mood. A progressive disease, an unfixable disability, and so forth. Are you "depressed" then, or just legitimately sad?