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> They absolutely work for many people. Unfortunately, many people deprive themselves of SSRI trials because they read too many negative anecdotes online. If yo
by starpilot 7y ago
> They absolutely work for many people. Unfortunately, many people deprive themselves of SSRI trials because they read too many negative anecdotes online. If you're seriously depressed for an extended period of time, it's worth a trial of an SSRI medication. If it doesn't work, just taper off and be done with it. At least you'll know.
SSRI's do not work. Linked elsewhere in this thread: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/
> The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.
Serotonin being the key driver of depression is as wrong as complex carbs being the healthiest macronutrient.
- Pfhreak 7y agoA newer meta analysis from 2018 says they do work: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889788/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889788/ > We identified 28 552 citations and of these included 522 trials comprising 116 477 participants. In terms of efficacy, all antidepressants were more effective than placebo Anecdotally, SSRIs do work for some people, and it can be life changing.