I've actually set up Skype on Virtualbox with no problems. I needed to test a Skype plugin once and had 4 Skype instances running on the same machine (3 virtual

I've actually set up Skype on Virtualbox with no problems. I needed to test a Skype plugin once and had 4 Skype instances running on the same machine (3 virtual, one native). Later Skype versions break with Virtualbox, but older versions work fine.