Supplements, or "supplements"? I've heard that this is one of the dangers of the use of any kind of substantially-effective PED: not necessarily that their use

Supplements, or "supplements"? I've heard that this is one of the dangers of the use of any kind of substantially-effective PED: not necessarily that their use will disrupt physiological systems so greatly (though many do when abused), but that the difference in performance or physique while on vs off is so great that it discourages either working out while not using them, or else never getting off them.