5 ms·

Tocilizumab drug in Naples hospital seems promising: «The health of the patient suffering from covid 19, who arrived in critical condition, intubated and treate

by DrNuke 7y ago

Tocilizumab drug in Naples hospital seems promising: «The health of the patient suffering from covid 19, who arrived in critical condition, intubated and treated with the new drug therapy is recovering. Maybe we extubate him because his conditions have improved a lot ». They also say they got confirmation from Chinese colleagues who tested that earlier on 21 cases. The drug is now undergoing trial at Roche. https://www.corriere.it/video-articoli/2020/03/09/dopo-cina-anche-italia-test-un-farmaco-casi-gravi-ecco-risultati/9405aebc-622a-11ea-9897-5c6f48cf812d.shtml https://www.corriere.it/video-articoli/2020/03/09/dopo-cina-...

busyant 7y ago
If that turns out to be true, it's remarkable how many pathologies are related to our immune systems going haywire.
Someone1234 7y ago
I'm incredibly ignorant, can someone explain why a drug used to treat arthritis might work against a Coronavirus? I just don't understand the connection/interaction, or why this was even tried originally? Genuinely looking to learn.
- tbarbugli 7y ago
  it reduces the immune system reaction inflammatory reaction which can be fatal
- J_cst 7y ago
  The linked video has interesting explanation. Perhaps someone more versed may upload to YT to get a robotraslation to everybody's benefit?
- DrNuke 7y ago
  The two doctors in the video say that it interferes with a similar auto-immune reaction that happens at pulmonary level because of the Coronavirus, so that it works.
- autojoechen 7y ago
  One of the ways the virus kills the patient is causing a cytokine storm [0][1]. And tocilizumab suppresses one of the cytokines in humans [2]. 0: https://www.nationalgeographic.com/science/2020/02/here-is-what-coronavirus-does-to-the-body/ https://www.nationalgeographic.com/science/2020/02/here-is-w... 1: https://en.wikipedia.org/wiki/Cytokine_release_syndrome https://en.wikipedia.org/wiki/Cytokine_release_syndrome 2: https://en.wikipedia.org/wiki/Tocilizumab https://en.wikipedia.org/wiki/Tocilizumab
  - listsfrin 7y ago
    "It might be a cytokine storm".
- BjoernKW 7y ago
  Rheumatoid arthritis is an autoimmune disorder. The severe cases who contracted the Coronavirus seem to experience an autoimmune reaction towards otherwise healthy lung tissue.
- inferiorhuman 7y ago
  can someone explain why a drug used to treat arthritis Rheumatoid arthritis is an autoimmune disease and not a "oh I'm old and I've worn down all of my cartilage" disease.
tim333 7y ago
That and some other stuff http://en.people.cn/n3/2020/0307/c90000-9665722.html http://en.people.cn/n3/2020/0307/c90000-9665722.html Chloroquine remains quite promising for the early stages http://news.southcn.com/nfplus/gdjktt/content/2020-03/09/content_190536632.htm http://news.southcn.com/nfplus/gdjktt/content/2020-03/09/con...
- agumonkey 7y ago
  so we're gonna a see a n-therapy to cover the whole span ?
fspeech 7y ago
Note this is a last resort move for patients in critical condition.
- DrNuke 7y ago
  It would serve well to avoid the collapse of hospitals’ critical units indeed.
hokkos 7y ago
cytokines storm in only one of the many ways coronavirus can kill, lungs failure, trachea obstruction from mucus, are others.

by DrNuke 7y ago

busyant 7y ago

If that turns out to be true, it's remarkable how many pathologies are related to our immune systems going haywire.

Someone1234 7y ago

I'm incredibly ignorant, can someone explain why a drug used to treat arthritis might work against a Coronavirus? I just don't understand the connection/interaction, or why this was even tried originally? Genuinely looking to learn.

tbarbugli 7y ago
it reduces the immune system reaction inflammatory reaction which can be fatal
J_cst 7y ago
The linked video has interesting explanation. Perhaps someone more versed may upload to YT to get a robotraslation to everybody's benefit?
DrNuke 7y ago
The two doctors in the video say that it interferes with a similar auto-immune reaction that happens at pulmonary level because of the Coronavirus, so that it works.
autojoechen 7y ago
One of the ways the virus kills the patient is causing a cytokine storm [0][1]. And tocilizumab suppresses one of the cytokines in humans [2]. 0: https://www.nationalgeographic.com/science/2020/02/here-is-what-coronavirus-does-to-the-body/ https://www.nationalgeographic.com/science/2020/02/here-is-w... 1: https://en.wikipedia.org/wiki/Cytokine_release_syndrome https://en.wikipedia.org/wiki/Cytokine_release_syndrome 2: https://en.wikipedia.org/wiki/Tocilizumab https://en.wikipedia.org/wiki/Tocilizumab
- listsfrin 7y ago
  "It might be a cytokine storm".
BjoernKW 7y ago
Rheumatoid arthritis is an autoimmune disorder. The severe cases who contracted the Coronavirus seem to experience an autoimmune reaction towards otherwise healthy lung tissue.
inferiorhuman 7y ago
can someone explain why a drug used to treat arthritis Rheumatoid arthritis is an autoimmune disease and not a "oh I'm old and I've worn down all of my cartilage" disease.

tim333 7y ago

That and some other stuff http://en.people.cn/n3/2020/0307/c90000-9665722.html http://en.people.cn/n3/2020/0307/c90000-9665722.html Chloroquine remains quite promising for the early stages http://news.southcn.com/nfplus/gdjktt/content/2020-03/09/content_190536632.htm http://news.southcn.com/nfplus/gdjktt/content/2020-03/09/con...

agumonkey 7y ago
so we're gonna a see a n-therapy to cover the whole span ?

fspeech 7y ago

Note this is a last resort move for patients in critical condition.

DrNuke 7y ago
It would serve well to avoid the collapse of hospitals’ critical units indeed.

hokkos 7y ago

cytokines storm in only one of the many ways coronavirus can kill, lungs failure, trachea obstruction from mucus, are others.