4 ms·

> If it's not in clinical trials yet Only if its harmful. What if the drug has been in use for other disease with known side effects, will we still wait for cl

> If it's not in clinical trials yet Only if its harmful. What if the drug has been in use for other disease with known side effects, will we still wait for clinical trials?

denzil_correa 7y ago
It depends on the risk profile. A loss of hair for a cancer drug won't be a big deal but might be problematic for common cold.
- tenant 7y ago
  I won't have that side effect anyway
  - vincnetas 7y ago
    Took me a while, but i see what you did there ;)
    - malkia 7y ago
      Yes, same here - I'm the star of the Bald & Beautiful in my family, but I don't want to influence my receding hair choices to them, unless you plan on landing male role in future Fast & Furious, Die Hard, or any Rock-infused movie.
- jfkebwjsbx 7y ago
  This is no common cold, specially for people 60+ years old.
oldgradstudent 7y ago
It depends whether you want to know if it actually works.
DuskStar 7y ago
Even if it's already approved for human use, we still need to test for efficacy before prescribing it to everyone. See also: remdesivir, favipiravir, Prezcobix, chloroquine and ruxolitinib, among many others.
- craftinator 7y ago
  Why? If side effects are marginal and well understood, just start using it and see how well it does.
  - DuskStar 7y ago
    What's the functional difference between that and a clinical trial, from the perspective of the patients?
    - internet_user 7y ago
      It would be essentially a clinical trial, an open-label one. There even have been several blinded trials, that were discontinued mid-way, because the drugs being tested were so effective. To continue giving placebo and denying obvious cure would be unethical, and so the trial was stopped, placebo arm cancelled - and everyone got the actual medicine.
    - ferzul 7y ago
      in a trial, you get invited and you might be placeboed out as a control. in the “just try it and see scenario”, you offer it as a possibility, and everyone who ops in, gets it. it might not be as scientifically rigorous, but that's a big difference to the patient who suffers from receiving a placebo instead of the real deal
petra 7y ago
“It does require trials in humans to determine if it’s effective, and I suspect it would also require pre-clinical animal work with SARS-CoV-2 specifically before human trials could start. If it has been shown to be safe for clinical use in other countries, it may be fast-tracked for FDA approval or the FDA may authorize emergency off-label use[with no need for clinical trials],” said Rasmussen, indicating that the FDA will have to examine safety data and pre-clinical data before determining which, if any course of action to take with investigating the drug further. https://www.forbes.com/sites/victoriaforster/2020/03/03/there-is-a-drug-already-used-in-japan-which-may-treat-covid-19-says-new-study/#587ec5624127 https://www.forbes.com/sites/victoriaforster/2020/03/03/ther...

> If it's not in clinical trials yet Only if its harmful. What if the drug has been in use for other disease with known side effects, will we still wait for clinical trials?

denzil_correa 7y ago

It depends on the risk profile. A loss of hair for a cancer drug won't be a big deal but might be problematic for common cold.

tenant 7y ago
I won't have that side effect anyway
- vincnetas 7y ago
  Took me a while, but i see what you did there ;)
  - malkia 7y ago
    Yes, same here - I'm the star of the Bald & Beautiful in my family, but I don't want to influence my receding hair choices to them, unless you plan on landing male role in future Fast & Furious, Die Hard, or any Rock-infused movie.
jfkebwjsbx 7y ago
This is no common cold, specially for people 60+ years old.

oldgradstudent 7y ago

It depends whether you want to know if it actually works.

DuskStar 7y ago

Even if it's already approved for human use, we still need to test for efficacy before prescribing it to everyone. See also: remdesivir, favipiravir, Prezcobix, chloroquine and ruxolitinib, among many others.

craftinator 7y ago
Why? If side effects are marginal and well understood, just start using it and see how well it does.
- DuskStar 7y ago
  What's the functional difference between that and a clinical trial, from the perspective of the patients?
  - internet_user 7y ago
    It would be essentially a clinical trial, an open-label one. There even have been several blinded trials, that were discontinued mid-way, because the drugs being tested were so effective. To continue giving placebo and denying obvious cure would be unethical, and so the trial was stopped, placebo arm cancelled - and everyone got the actual medicine.
  - ferzul 7y ago
    in a trial, you get invited and you might be placeboed out as a control. in the “just try it and see scenario”, you offer it as a possibility, and everyone who ops in, gets it. it might not be as scientifically rigorous, but that's a big difference to the patient who suffers from receiving a placebo instead of the real deal

petra 7y ago

“It does require trials in humans to determine if it’s effective, and I suspect it would also require pre-clinical animal work with SARS-CoV-2 specifically before human trials could start. If it has been shown to be safe for clinical use in other countries, it may be fast-tracked for FDA approval or the FDA may authorize emergency off-label use[with no need for clinical trials],” said Rasmussen, indicating that the FDA will have to examine safety data and pre-clinical data before determining which, if any course of action to take with investigating the drug further. https://www.forbes.com/sites/victoriaforster/2020/03/03/there-is-a-drug-already-used-in-japan-which-may-treat-covid-19-says-new-study/#587ec5624127 https://www.forbes.com/sites/victoriaforster/2020/03/03/ther...