4 ms·
Million-dollar question: what kind of cellular dysfunction would be caused by blockading ACE2 and TMPRSS2?
by forkexec 7y ago
Million-dollar question:
what kind of cellular dysfunction would be caused by blockading ACE2 and TMPRSS2?
- forkexec 7y agoACE2 has direct effects on cardiac functiona and is expressed predominantly in vascular endothelial cells of the heart and the kidneys. -wikipedia ACE2 entry is [betacoronavirus] lineage B clade 1 specific. ----- TMPRSS2 ----- • positive regulation of viral entry into host cell • protein autoprocessing • receptor-mediated endocytosis • proteolysis • vesicle-mediated transport • endocytosis This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. The biological function of this gene is unknown. - wikipedia Interestingly, TMPRSS2 is the same exact pathway used by SARS, murine respirovirus and influenza. So, a blockade or modification of this might be a way to cure the flu as well. TMPRSS2 entry is found in betacoronavirus lineage B, but not specific to it.