5 ms·

camostat mesylate + E-64d Camostat CAS: 59721-29-8 Approvals: Japan $0.10/mg in bulk (2 week lead time), or $1.25/mg in-stock https://en.wikipedia.org/wiki

camostat mesylate + E-64d Camostat CAS: 59721-29-8 Approvals: Japan $0.10/mg in bulk (2 week lead time), or $1.25/mg in-stock https://en.wikipedia.org/wiki/Camostat https://en.wikipedia.org/wiki/Camostat https://www.adooq.com/camostat-mesylate.html https://www.adooq.com/camostat-mesylate.html https://www.medkoo.com/products/11665 https://www.medkoo.com/products/11665 ---------- E-64d CAS: 88321-09-9 LD50 in rats: >100000 mg/kg $12.5/mg in-stock https://www.sigmaaldrich.com/catalog/product/sigma/e8640 https://www.sigmaaldrich.com/catalog/product/sigma/e8640 https://www.apexbt.com/e-64d.html https://www.apexbt.com/e-64d.html ---------- Obviously: untested, unknown dosage and not FDA approved. It would need a little DMSO to dissolve both.

lm28469 7y ago
Yes, definitely self medicate with untested drugs for what basically is the flu as long as you're under 60 years old, what could possibly go wrong ...
- missosoup 7y ago
  At a lower bound estimate of 30-60x the case fatality rate of flu and some unexplained reinfection mechanism, 'it's just the flu bro' is getting really disingenuous. A simple way to explain this to simple minded people is: ever heard of international travel and massive sports events being cancelled, and armies getting mobilised because of just the flu? No? That's because that's not what this is. Poster made it clear that the drug is untested an experimental, but ultimately each individual is responsible for their own wellbeing and should be aware of last-ditch options if things get dire.
  - lm28469 7y ago
    > 30-60x the case fatality Under 60 years old, certainly not. > some unexplained reinfection mechanism unexplained and more importantly totally unproven. It certainly is more dangerous than the flu but if you're not weak or old taking some random untested drugs recommended on an internet forum by someone who has no idea what he's talking about is most likely more risky than just following health organisations recommendations.
    - missosoup 7y ago
      > unexplained and more importantly totally unproven. What do you mean unproven? There are reinfection cases with incredibly low latencies being reported all over the globe. A handful of reports might be written off as misunderstandings or outliers but there are multiple reports per day from reputable sources. Reinfection is certainly a factor, the only question is by what mechanism. https://www.scmp.com/news/china/society/article/3048320/china-coronavirus-deadly-day-hubei-record-high-42-patients-die https://www.scmp.com/news/china/society/article/3048320/chin... https://twitter.com/OH_mes2/status/1233346594428186627 https://twitter.com/OH_mes2/status/1233346594428186627 > weak or old Does a 29 year old healthy male sound weak or old? https://twitter.com/lilkuo/status/1230699297508745217 https://twitter.com/lilkuo/status/1230699297508745217 > just following health organisations recommendations You mean like the CDC which is being actively dismantled while the president of the US goes on national TV and calls their messaging fake news? The health of every individual is ultimately in their own hands. Being informed of everything pertinent to their health including experimental last-ditch treatments is in everyone's interest. Don't look to authorities to babysit you through a pandemic, especially not in poor countries or USA. By hitting the downvote button on the grandparent comment, you're electing to censor it in some sort of misguided do-gooding effort, inspite of HN guidelines.
      - xorfish 7y ago
        A false negative doesn't make a reinfection. There are going to be a lot of still positive people that test negative with a test that has a high enough false negative rate.
        missosoup 7y ago
        Patients only get retested after they appear to have recovered. That means their symptoms have subsided. You can get super pedantic with semantics and call it a false negative, which might be technically true if the virus subsides but has the ability to persist - which is one of the potential mechanisms for reinfection, but has not been confirmed. But none of that changes the fact that people are getting reinfected and sometimes dropping dead after appearing to have recovered by all measures. This is clearly different to 'it's just the flu bro'.
  - LoSboccacc 7y ago
    > estimate of 30-60x the case fatality rate of flu so what do you call comparing cfr of a novel disease that so far has often went unreported, had a small sample size, is often misdiagnosed with pneumonia or the common flu and has no immunization, with another where people at risk get vaccinations and there's large statistical data coming from decades of modern countries tracking strains efficiently? no, comparing cfrs is disingenuous. not to say that this disease isn't severe, but enough already with the flu multipliers. it's bullshit and is not making any point across.
    - missosoup 7y ago
      Flu multipliers are the most effective way to convey the risk of this disease to simple-minded people who dismiss it as 'just the flu'. In a more technical context, I would entirely agree with you and not use such figures.
      - LoSboccacc 7y ago
        yeah but people will look up the figures, figure out the statistics are misleading, and be even more entrenched in their 'just the flu' assumption. there needs to be a better way and I think "your elders' and your friends elders' are vaccinated against the flu, not this and are gonna catch it from you and 30%^ of them straight up dies" seems a better angle and more solid against argumentation. ^ or whatever % is today
  - refurb 7y ago
    30-60x the case fatality rate of flu 30-60x the risk of something that happens very, very rarely, is still a very small risk.

lm28469 7y ago

Yes, definitely self medicate with untested drugs for what basically is the flu as long as you're under 60 years old, what could possibly go wrong ...

missosoup 7y ago
At a lower bound estimate of 30-60x the case fatality rate of flu and some unexplained reinfection mechanism, 'it's just the flu bro' is getting really disingenuous. A simple way to explain this to simple minded people is: ever heard of international travel and massive sports events being cancelled, and armies getting mobilised because of just the flu? No? That's because that's not what this is. Poster made it clear that the drug is untested an experimental, but ultimately each individual is responsible for their own wellbeing and should be aware of last-ditch options if things get dire.
- lm28469 7y ago
  > 30-60x the case fatality Under 60 years old, certainly not. > some unexplained reinfection mechanism unexplained and more importantly totally unproven. It certainly is more dangerous than the flu but if you're not weak or old taking some random untested drugs recommended on an internet forum by someone who has no idea what he's talking about is most likely more risky than just following health organisations recommendations.
  - missosoup 7y ago
    > unexplained and more importantly totally unproven. What do you mean unproven? There are reinfection cases with incredibly low latencies being reported all over the globe. A handful of reports might be written off as misunderstandings or outliers but there are multiple reports per day from reputable sources. Reinfection is certainly a factor, the only question is by what mechanism. https://www.scmp.com/news/china/society/article/3048320/china-coronavirus-deadly-day-hubei-record-high-42-patients-die https://www.scmp.com/news/china/society/article/3048320/chin... https://twitter.com/OH_mes2/status/1233346594428186627 https://twitter.com/OH_mes2/status/1233346594428186627 > weak or old Does a 29 year old healthy male sound weak or old? https://twitter.com/lilkuo/status/1230699297508745217 https://twitter.com/lilkuo/status/1230699297508745217 > just following health organisations recommendations You mean like the CDC which is being actively dismantled while the president of the US goes on national TV and calls their messaging fake news? The health of every individual is ultimately in their own hands. Being informed of everything pertinent to their health including experimental last-ditch treatments is in everyone's interest. Don't look to authorities to babysit you through a pandemic, especially not in poor countries or USA. By hitting the downvote button on the grandparent comment, you're electing to censor it in some sort of misguided do-gooding effort, inspite of HN guidelines.
    - xorfish 7y ago
      A false negative doesn't make a reinfection. There are going to be a lot of still positive people that test negative with a test that has a high enough false negative rate.
      - missosoup 7y ago
        Patients only get retested after they appear to have recovered. That means their symptoms have subsided. You can get super pedantic with semantics and call it a false negative, which might be technically true if the virus subsides but has the ability to persist - which is one of the potential mechanisms for reinfection, but has not been confirmed. But none of that changes the fact that people are getting reinfected and sometimes dropping dead after appearing to have recovered by all measures. This is clearly different to 'it's just the flu bro'.
- LoSboccacc 7y ago
  > estimate of 30-60x the case fatality rate of flu so what do you call comparing cfr of a novel disease that so far has often went unreported, had a small sample size, is often misdiagnosed with pneumonia or the common flu and has no immunization, with another where people at risk get vaccinations and there's large statistical data coming from decades of modern countries tracking strains efficiently? no, comparing cfrs is disingenuous. not to say that this disease isn't severe, but enough already with the flu multipliers. it's bullshit and is not making any point across.
  - missosoup 7y ago
    Flu multipliers are the most effective way to convey the risk of this disease to simple-minded people who dismiss it as 'just the flu'. In a more technical context, I would entirely agree with you and not use such figures.
    - LoSboccacc 7y ago
      yeah but people will look up the figures, figure out the statistics are misleading, and be even more entrenched in their 'just the flu' assumption. there needs to be a better way and I think "your elders' and your friends elders' are vaccinated against the flu, not this and are gonna catch it from you and 30%^ of them straight up dies" seems a better angle and more solid against argumentation. ^ or whatever % is today
- refurb 7y ago
  30-60x the case fatality rate of flu 30-60x the risk of something that happens very, very rarely, is still a very small risk.