3 ms·

Is it the case that SARS (of many years ago) had a vaccine developed for it, but it had too many side effects or was not effective enough to get past trials?

Is it the case that SARS (of many years ago) had a vaccine developed for it, but it had too many side effects or was not effective enough to get past trials? And that while this virus is different it is similar in many respects... leading me to think that a vaccine may also be difficult to produce.

koheripbal 7y ago
By the time the SARS vaccine was nearly completed testing, the outbreak had burned out.
daxorid 7y ago
Yes, the SARS vaccine virtually guaranteed severe lung scarring if you were re-exposed to full-strength SARS: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421 https://journals.plos.org/plosone/article?id=10.1371/journal...
- UncleOxidant 7y ago
  Would this also the case if someone who had SARS and recovered was re-exposed to SARS?
allovernow 7y ago
There was is one paper[0] where 4 candidates were tested on a number of animal species. In all but one variant, immunity was successfully conferred by the vaccine. However, in all successful cases, the vaccines triggered some sort of autoimmune response wherin upon exposure to the pathogen post vaccination, lung damage resulted[0]. Now I believe this has something to do with another nefarious speculated property of SARS-CoV-2: Antibody Dependent Enhancement (ADE). Can't find the original source but here[1] researchers also speculate about ADE. The gist is that your antibodies, instead of neutralizing the virus, actually enhance its ability to enter your cells[2]. I don't know if this is confirmed, but multiple sources have made the suggestion. If this is the case, typical vaccines actually may be dangerous. Now I'm not not an expert but I believe there is a way to create a vaccine which avoids ADE, but AFAIK that hasn't been done for the previous SARS strain. This was a problem with MERS too btw. 0. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421 https://journals.plos.org/plosone/article?id=10.1371/journal... Credit to user daxorid for the link. 1. https://www.virosin.org/fileZGBDX/journal/article/vs/newcreate/0216.pdf https://www.virosin.org/fileZGBDX/journal/article/vs/newcrea... 2. https://en.m.wikipedia.org/wiki/Antibody-dependent_enhancement https://en.m.wikipedia.org/wiki/Antibody-dependent_enhanceme...

koheripbal 7y ago

By the time the SARS vaccine was nearly completed testing, the outbreak had burned out.

daxorid 7y ago

Yes, the SARS vaccine virtually guaranteed severe lung scarring if you were re-exposed to full-strength SARS: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421 https://journals.plos.org/plosone/article?id=10.1371/journal...

UncleOxidant 7y ago
Would this also the case if someone who had SARS and recovered was re-exposed to SARS?

allovernow 7y ago

There was is one paper[0] where 4 candidates were tested on a number of animal species. In all but one variant, immunity was successfully conferred by the vaccine. However, in all successful cases, the vaccines triggered some sort of autoimmune response wherin upon exposure to the pathogen post vaccination, lung damage resulted[0]. Now I believe this has something to do with another nefarious speculated property of SARS-CoV-2: Antibody Dependent Enhancement (ADE). Can't find the original source but here[1] researchers also speculate about ADE. The gist is that your antibodies, instead of neutralizing the virus, actually enhance its ability to enter your cells[2]. I don't know if this is confirmed, but multiple sources have made the suggestion. If this is the case, typical vaccines actually may be dangerous. Now I'm not not an expert but I believe there is a way to create a vaccine which avoids ADE, but AFAIK that hasn't been done for the previous SARS strain. This was a problem with MERS too btw. 0. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421 https://journals.plos.org/plosone/article?id=10.1371/journal... Credit to user daxorid for the link. 1. https://www.virosin.org/fileZGBDX/journal/article/vs/newcreate/0216.pdf https://www.virosin.org/fileZGBDX/journal/article/vs/newcrea... 2. https://en.m.wikipedia.org/wiki/Antibody-dependent_enhancement https://en.m.wikipedia.org/wiki/Antibody-dependent_enhanceme...