Which part is not true? I'll accept 'exaggeration', because pristine is probably not the best word, but it absolutely becomes harder to pass all of the criteri

Which part is not true? I'll accept 'exaggeration', because pristine is probably not the best word, but it absolutely becomes harder to pass all of the criteria for a trial once you start getting deeper into treatment (e.g. 4+ cycles of chemo). This is particularly true for immunotherapy trials, but things like brain mets can disqualify someone from a huge swath of trials, regardless of how active they are. This all makes sense if you're looking at trials as a way to determine if a therapy works. If you're looking at them as a way to access experimental medicine, however, it is pretty disappointing.