5 ms·

This seems to be overstating things. > COVID-19 seems to be most severe in older adults. The median age of deaths is 75. I guess that’s technically “older ad

This seems to be overstating things. > COVID-19 seems to be most severe in older adults. The median age of deaths is 75. I guess that’s technically “older adults” but I think “elderly” would be a better description. https://www.nytimes.com/2020/01/23/world/asia/coronavirus-victims-wuhan.html https://www.nytimes.com/2020/01/23/world/asia/coronavirus-vi... > there are a number of indications that it will be very much like the 1918 Flu Pandemic The New England Journal of Medicine has a different take: https://www.nejm.org/doi/full/10.1056/NEJMe2002387 https://www.nejm.org/doi/full/10.1056/NEJMe2002387 It sounds increasingly likely that the fatality rate is less than 1%, potentially a lot less, as were now hearing that 80% of people don’t even get sick enough to seek medical attention, and many have no signs of illness at all — which means the denominator in the death rate is likely much higher than is accounted for in the common 2% metric from the first data. > Expect people you know to die. Aside from this likely being inaccurate, is this language even remotely helpful?

gamegoblin 7y ago
What puts it in more relatable terms for me is if the death rate for elderly is 1 in 10, and the virus spreads into "basically everyone will get it" territory, statistically that will be several funerals for elderly family and friends I will attend this year. And while that isn't society-ending apocalypse, it's still impactful on a personal level.
- fiblye 7y ago
  That statistic still only takes into account known and confirmed infections. Most reported deaths are from people who have other major health issues. With reports of people being infected in nursing homes, there's a possibility that even the elderly are being silently infected and symptoms aren't severe enough for them to seek treatment. It seems like there's some unknown factor that makes some people extremely sensitive to it, while others feel nothing at all.
  - notacoward 7y ago
    > Most reported deaths are from people who have other major health issues. The percentage of people 70+ who have "other major health issues" is higher than you seem to think. People who are themselves in their 40s or 50s are likely to know several. Maybe that's not as true for people in their 20s, especially those who live within a closed social circle of mostly their FAANG/startup coworkers, but it's a bit insensitive (at best) to act as though that's true for everyone.
    - fiblye 7y ago
      Thanks for the completely inaccurate personal attack. :) News articles regarding this have been very explicit about saying the victims have notable health problems and not simply age. e.g., A long history of lung problems, cancer, etc. Plenty of old people are recovering fine, and I'm sure the reason health issues are mentioned is because those people have exceptionally bad health in some way. I don't think anyone really doesn't know that old people are less healthy overall. It's bizarre that some people think they need to explain that fact in a condescending manner.
      - notacoward 7y ago
        As Frank Herbert once wrote: "My son displays a general garment and you claim it's cut to your fit. What a fascinating revelation." It wasn't a personal attack. It's not my problem if you chose to apply it to yourself. But enough of your meta-discussion. You displayed an all too common misunderstanding about how (un)healthy older people are, so I challenged it. Here are some figures on co-morbidity factors for Covid-19. * Cardiovascular disease 13.2% * Diabetes 9.2% * Chronic respiratory disease 8.0% * Hypertension 8.4% * Cancer 7.6% (all from https://www.worldometers.info/coronavirus/coronavirus-age-sex-demographics/ https://www.worldometers.info/coronavirus/coronavirus-age-se...) So, how common are these issues in the 70+ crowd? * 25-35% of US adults 65 or over have cardiovascular disease (range due to gender difference) * 19-23% have diabetes * 8-9% have asthma, 21-26% have bronchitis or emphysema (oddly the numbers don't cover COPD which I believe is around 15%) * 55-57% have hypertension * 21-26% have cancer at some point (all from https://agingstats.gov/docs/LatestReport/Older-Americans-2016-Key-Indicators-of-WellBeing.pdf https://agingstats.gov/docs/LatestReport/Older-Americans-201...) Given those numbers, what percentage of older people do you suppose have escaped all of those ills? Clearly less than half. So of course most of the elderly who have died from Covid-19 already had some other condition, because most of the elderly period have some other condition. Assuming the existence of vast numbers of elderly without such conditions for the sake of your argument is just not helpful. Your turn. Bring some facts to the table instead of wild supposition and complaints.
- golergka 7y ago
  > What puts it in more relatable terms for me is if the death rate for elderly is 1 in 10 I have 4 living grandparents - which means that odds of my attending a funeral in the next year or so is at least 35%. That's horrifying.
jansan 7y ago
Huge difference to Spanish Flu is that at that time we did not have antibiotics and most people did not die from the flu, but from pneumonia caused by a bacterial superinfection. Thanks to Alexander Fleming and other great researchers we can treat bacterial infections quite well now, so the corona virus would have to be a lot more lethal than the Spanish Flu to cause the same number of deaths.
- nostromo 7y ago
  Not to mention a brutal world war. I can't think of a worse time to have a pandemic. A̶n̶t̶i̶b̶i̶o̶t̶i̶c̶s̶ ̶w̶o̶n̶'̶t̶ ̶h̶e̶l̶p̶ ̶w̶i̶t̶h̶ ̶C̶O̶V̶I̶D̶-̶1̶9̶,̶ ̶b̶u̶t̶ ̶w̶e̶ ̶h̶a̶v̶e̶ ̶a̶ ̶l̶o̶t̶ ̶o̶f̶ ̶a̶n̶t̶i̶v̶i̶r̶a̶l̶s̶ ̶n̶o̶w̶ ̶t̶h̶a̶t̶ ̶m̶a̶y̶ ̶h̶e̶l̶p̶,̶ ̶a̶n̶d̶ ̶m̶u̶c̶h̶ ̶h̶i̶g̶h̶e̶r̶ ̶s̶t̶a̶n̶d̶a̶r̶d̶s̶ ̶o̶f̶ ̶c̶a̶r̶e̶.̶ Edit: Thanks for the correction below, I misunderstood why antibiotics could be of help.
  - djmips 7y ago
    I think his thesis is that the 1918 flu allowed co-infection with bacterial pneumonia which could probably be treated today.
azinman2 7y ago
That number will vary greatly by region and the quality of healthcare, as well as the functioning ability of governments to handle it. The infection rate is such that it’s exponentially growing, which means it’s showing no signs of slowing down. If 1% of the world dies from it, that’s hundreds of millions of people dying from something in addition to everything else already killing people. This is really bad.
- nostromo 7y ago
  > The infection rate is such that it’s exponentially growing Globally speaking, that's not the case. The number of new cases was highest in early to mid-February and has been lower in the past two weeks.
  - distrill 7y ago
    > The number of new cases was highest in early to mid-February and has been lower in the past two weeks. What? That doesn't matter at all. The number of new cases globally is growing at an increasing rate- the number will eclipse that from early-mid february shortly.
    - nostromo 7y ago
      > The number of new cases globally is growing at an increasing rate That's just not true. The daily increase in total cases globally has been going down since mid February. https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594... (Link fixed, thanks)
      - samvher 7y ago
        I can't see anything at your link - first it asks for a login, then I login with Google and get an error. Here [1] it looks like for a while around mid february the daily increase was getting less, but it's picking up again. [1] https://www.worldometers.info/coronavirus/ https://www.worldometers.info/coronavirus/
teekert 7y ago
The "die" part is why this gets shared. Expect more of these messages.
- nostromo 7y ago
  Exactly. It's almost clickbait.
edna314 7y ago
The crude case fatality rate is somewhat a hard to interpret number, since it not only depends on the number of fatalities but also on the number of diagnosed people. Differences in how many people are diagnosed mostly explains the regional differences we see in CFR for covid-19. This also makes it hard to compare to the Spanish flu since we don’t know how many infected were diagnosed back then.
mrb 7y ago
This NEJM article you referenced (https://www.nejm.org/doi/full/10.1056/NEJMe2002387 https://www.nejm.org/doi/full/10.1056/NEJMe2002387) is a poor estimate of the Case Fatality Ratio. I'm perplexed it passed peer-review (I'm not even an expert, so why am I finding such glaring flaws?) It's citing two references (ref. 4 and ref. 5) that estimate CFR at respectively 2% and 1.4%, however both use the naïve CFR formula (deaths/cases) that's known to underestimate the CFR due to deaths lagging cases in a rapidly growing outbreak. I wrote about this bias and provided 5 peer-reviewed epidemiological papers that also document it, see: https://blog.zorinaq.com/case-fatality-ratio-ncov/ https://blog.zorinaq.com/case-fatality-ratio-ncov/ Then it remarks that many mild cases are probably not detected (ie. high underascertainment) but strangely makes no effort at quantifying it, or referencing other papers that do quantify it. The 4 best published studies that correct for these two aspects (naïve CFR bias + underascertainment) are: https://www.mdpi.com/2077-0383/9/2/523 https://www.mdpi.com/2077-0383/9/2/523 https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-2019-nCoV-severity-10-02-2020.pdf https://www.imperial.ac.uk/media/imperial-college/medicine/s... https://institutefordiseasemodeling.github.io/nCoV-public/analyses/first_adjusted_mortality_estimates_and_risk_assessment/2019-nCoV-preliminary_age_and_time_adjusted_mortality_rates_and_pandemic_risk_assessment.html https://institutefordiseasemodeling.github.io/nCoV-public/an... https://github.com/calthaus/ncov-cfr/blob/d30f02e1c20e06103aad6a04eb492dd156466d98/README.md https://github.com/calthaus/ncov-cfr/blob/d30f02e1c20e06103a... (3 of the 4 above studies are even referenced by the WHO in their Coronavirus disease situation report 30 (references 10, 11 and 12) and in situation report 31: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200219-sitrep-30-covid-19.pdf https://www.who.int/docs/default-source/coronaviruse/situati... and https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200220-sitrep-31-covid-19.pdf https://www.who.int/docs/default-source/coronaviruse/situati... ) And they all estimate the CFR to be between 0.5% and 1.6%, or about 5x to 16x deadlier than the flu (0.1%)
- nodamage 7y ago
  Thank you for sharing this. I keep seeing people try to claim "but we don't know the true number of unreported cases therefore the true CFR is lower than reported" as if epidemiologists are somehow unaware of this factor.
cbolton 7y ago
> > Expect people you know to die. > Aside from this likely being inaccurate, is this language even remotely helpful? If it is accurate I appreciate someone informing me in brief and plain terms.
miked85 7y ago
> Expect people you know to die. > There will be significant economic disruption > Daily life will be impacted in important ways > The acute pandemic will probably last at least for several months and quite possibly for a year or two. Agreed, this seems very sensationalist. Any or all of the above could be true, but at best, she is guessing right now.
gexla 7y ago
Right, it's still an unknown, which is why there's such a great concern. As I have said before, if you are going to make a bet, you need to know the odds. We don't know the odds yet. This also means that we can't be sure of any of these numbers. Maybe the correct way to think of this isn't "people you know will die" but rather "people you know may die, so we need to be paranoid and prepare."
inciampati 7y ago
Genomic estimates suggest that there may be several thousand infected individuals, maybe many thousand, in Washington state. But we are only aware of a small handful of them. One explanation for this would be that many people are completely asymptomatic, or can't distinguish COVID-19 from a very mild cold. That would be in line with the NEJM article you shared, and explain why there haven't been any cases in children. If they don't have a strong enough reaction to require treatment or testing then it would seem they don't even get infected under the metrics that are established. The major problem is systemic risk from many people requiring intensive care all at once. The author of the linked blog post didn't mention an important and unsettling feature of the Spanish flu. It came in three waves. The first looked very similar to a bad seasonal flu or the current SARS outbreak. The second was the one that killed, by inducing a cytokine storm and immune overreaction in otherwise healthy, younger people. Deaths sometimes occurred in a matter of hours after the first appearance symptoms. Having an incredibly infectious virus cause a pandemic is one thing. Let's hope that we can monitor it's evolution to ensure that strains that it develops aren't significantly more dangerous. Its infectivity means that it will have a massive environment in which to evolve. Evolution rate is largely determined by population size.
bakul 7y ago
Here is an interesting comparison of mortality rate by age for SARS-Cov-2, 1918 'flu and seasonal 'flu: https://raw.githubusercontent.com/jbloom/CoV_vs_flu_CFR/master/CFR-stats.jpg https://raw.githubusercontent.com/jbloom/CoV_vs_flu_CFR/mast... Some context: https://twitter.com/petrakle/status/1234587264904318978 https://twitter.com/petrakle/status/1234587264904318978 This is based on data published so far.
pbourke 7y ago
In addition to this piece, there is this interview with Harvard Epidemiologist Marc Lipsitch [1]: > Whatever the number is, it's gonna take a toll. If it really does spread as widely as that projection says, and that's what I think is likely to happen, then there are gonna be millions of people dying. And I don't think there's any way to get around that. And so I think there's real reason for people to be concerned. I also think that we can turn that concern into actions that will make the situation better. I think pieces like this and the linked interview with Marc Lipsitch, which are clear-eyed reads on the situation from experts, should break through to the general public so they can take some action. [1] https://www.cbsnews.com/news/coronavirus-infection-outbreak-worldwide-virus-expert-warning-today-2020-03-02/ https://www.cbsnews.com/news/coronavirus-infection-outbreak-...
brownbat 7y ago
Dr. Fauci's iceberg theory, that the cfr will decline as we identify more mild cases, is disputed by some in the WHO and some Chinese scientists, who argue the CFR is well supported from comprehensive testing of quarantined populations, which identify and account for mild and asymptomatic cases. One such study: http://www.cidrap.umn.edu/news-perspective/2020/02/study-72000-covid-19-patients-finds-23-death-rate http://www.cidrap.umn.edu/news-perspective/2020/02/study-720... While the specific r0 and cfr are still under debate, there's no doubt this has rapidly absorbed hospital resources in hotspots in ways other coronaviruses haven't. I don't think panic is the right answer, but people should prepare for the possibility this impacts their lives, judging from regions with cases and the continued spread to new regions. Quarantines, social distancing, fewer public activities, and extended hospitalizations of some older family members are all realistic scenarios.
notacoward 7y ago
> It sounds increasingly likely that the fatality rate is less than 1% If enough people get it badly enough to require significant medical care, that will quickly overwhelm hospitals, and the fatality rate among those turned away will be much higher. We're more likely to follow the Iran pattern (CFR = 5.5%) than that from Japan or South Korea or even China.
deleted 7y ago
[deleted]

gamegoblin 7y ago

What puts it in more relatable terms for me is if the death rate for elderly is 1 in 10, and the virus spreads into "basically everyone will get it" territory, statistically that will be several funerals for elderly family and friends I will attend this year. And while that isn't society-ending apocalypse, it's still impactful on a personal level.

fiblye 7y ago
That statistic still only takes into account known and confirmed infections. Most reported deaths are from people who have other major health issues. With reports of people being infected in nursing homes, there's a possibility that even the elderly are being silently infected and symptoms aren't severe enough for them to seek treatment. It seems like there's some unknown factor that makes some people extremely sensitive to it, while others feel nothing at all.
- notacoward 7y ago
  > Most reported deaths are from people who have other major health issues. The percentage of people 70+ who have "other major health issues" is higher than you seem to think. People who are themselves in their 40s or 50s are likely to know several. Maybe that's not as true for people in their 20s, especially those who live within a closed social circle of mostly their FAANG/startup coworkers, but it's a bit insensitive (at best) to act as though that's true for everyone.
  - fiblye 7y ago
    Thanks for the completely inaccurate personal attack. :) News articles regarding this have been very explicit about saying the victims have notable health problems and not simply age. e.g., A long history of lung problems, cancer, etc. Plenty of old people are recovering fine, and I'm sure the reason health issues are mentioned is because those people have exceptionally bad health in some way. I don't think anyone really doesn't know that old people are less healthy overall. It's bizarre that some people think they need to explain that fact in a condescending manner.
    - notacoward 7y ago
      As Frank Herbert once wrote: "My son displays a general garment and you claim it's cut to your fit. What a fascinating revelation." It wasn't a personal attack. It's not my problem if you chose to apply it to yourself. But enough of your meta-discussion. You displayed an all too common misunderstanding about how (un)healthy older people are, so I challenged it. Here are some figures on co-morbidity factors for Covid-19. * Cardiovascular disease 13.2% * Diabetes 9.2% * Chronic respiratory disease 8.0% * Hypertension 8.4% * Cancer 7.6% (all from https://www.worldometers.info/coronavirus/coronavirus-age-sex-demographics/ https://www.worldometers.info/coronavirus/coronavirus-age-se...) So, how common are these issues in the 70+ crowd? * 25-35% of US adults 65 or over have cardiovascular disease (range due to gender difference) * 19-23% have diabetes * 8-9% have asthma, 21-26% have bronchitis or emphysema (oddly the numbers don't cover COPD which I believe is around 15%) * 55-57% have hypertension * 21-26% have cancer at some point (all from https://agingstats.gov/docs/LatestReport/Older-Americans-2016-Key-Indicators-of-WellBeing.pdf https://agingstats.gov/docs/LatestReport/Older-Americans-201...) Given those numbers, what percentage of older people do you suppose have escaped all of those ills? Clearly less than half. So of course most of the elderly who have died from Covid-19 already had some other condition, because most of the elderly period have some other condition. Assuming the existence of vast numbers of elderly without such conditions for the sake of your argument is just not helpful. Your turn. Bring some facts to the table instead of wild supposition and complaints.
golergka 7y ago
> What puts it in more relatable terms for me is if the death rate for elderly is 1 in 10 I have 4 living grandparents - which means that odds of my attending a funeral in the next year or so is at least 35%. That's horrifying.

jansan 7y ago

Huge difference to Spanish Flu is that at that time we did not have antibiotics and most people did not die from the flu, but from pneumonia caused by a bacterial superinfection. Thanks to Alexander Fleming and other great researchers we can treat bacterial infections quite well now, so the corona virus would have to be a lot more lethal than the Spanish Flu to cause the same number of deaths.

nostromo 7y ago
Not to mention a brutal world war. I can't think of a worse time to have a pandemic. A̶n̶t̶i̶b̶i̶o̶t̶i̶c̶s̶ ̶w̶o̶n̶'̶t̶ ̶h̶e̶l̶p̶ ̶w̶i̶t̶h̶ ̶C̶O̶V̶I̶D̶-̶1̶9̶,̶ ̶b̶u̶t̶ ̶w̶e̶ ̶h̶a̶v̶e̶ ̶a̶ ̶l̶o̶t̶ ̶o̶f̶ ̶a̶n̶t̶i̶v̶i̶r̶a̶l̶s̶ ̶n̶o̶w̶ ̶t̶h̶a̶t̶ ̶m̶a̶y̶ ̶h̶e̶l̶p̶,̶ ̶a̶n̶d̶ ̶m̶u̶c̶h̶ ̶h̶i̶g̶h̶e̶r̶ ̶s̶t̶a̶n̶d̶a̶r̶d̶s̶ ̶o̶f̶ ̶c̶a̶r̶e̶.̶ Edit: Thanks for the correction below, I misunderstood why antibiotics could be of help.
- djmips 7y ago
  I think his thesis is that the 1918 flu allowed co-infection with bacterial pneumonia which could probably be treated today.

azinman2 7y ago

That number will vary greatly by region and the quality of healthcare, as well as the functioning ability of governments to handle it. The infection rate is such that it’s exponentially growing, which means it’s showing no signs of slowing down. If 1% of the world dies from it, that’s hundreds of millions of people dying from something in addition to everything else already killing people. This is really bad.

nostromo 7y ago
> The infection rate is such that it’s exponentially growing Globally speaking, that's not the case. The number of new cases was highest in early to mid-February and has been lower in the past two weeks.
- distrill 7y ago
  > The number of new cases was highest in early to mid-February and has been lower in the past two weeks. What? That doesn't matter at all. The number of new cases globally is growing at an increasing rate- the number will eclipse that from early-mid february shortly.
  - nostromo 7y ago
    > The number of new cases globally is growing at an increasing rate That's just not true. The daily increase in total cases globally has been going down since mid February. https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594... (Link fixed, thanks)
    - samvher 7y ago
      I can't see anything at your link - first it asks for a login, then I login with Google and get an error. Here [1] it looks like for a while around mid february the daily increase was getting less, but it's picking up again. [1] https://www.worldometers.info/coronavirus/ https://www.worldometers.info/coronavirus/

teekert 7y ago

The "die" part is why this gets shared. Expect more of these messages.

nostromo 7y ago
Exactly. It's almost clickbait.

edna314 7y ago

The crude case fatality rate is somewhat a hard to interpret number, since it not only depends on the number of fatalities but also on the number of diagnosed people. Differences in how many people are diagnosed mostly explains the regional differences we see in CFR for covid-19. This also makes it hard to compare to the Spanish flu since we don’t know how many infected were diagnosed back then.

mrb 7y ago

This NEJM article you referenced (https://www.nejm.org/doi/full/10.1056/NEJMe2002387 https://www.nejm.org/doi/full/10.1056/NEJMe2002387) is a poor estimate of the Case Fatality Ratio. I'm perplexed it passed peer-review (I'm not even an expert, so why am I finding such glaring flaws?) It's citing two references (ref. 4 and ref. 5) that estimate CFR at respectively 2% and 1.4%, however both use the naïve CFR formula (deaths/cases) that's known to underestimate the CFR due to deaths lagging cases in a rapidly growing outbreak. I wrote about this bias and provided 5 peer-reviewed epidemiological papers that also document it, see: https://blog.zorinaq.com/case-fatality-ratio-ncov/ https://blog.zorinaq.com/case-fatality-ratio-ncov/ Then it remarks that many mild cases are probably not detected (ie. high underascertainment) but strangely makes no effort at quantifying it, or referencing other papers that do quantify it. The 4 best published studies that correct for these two aspects (naïve CFR bias + underascertainment) are: https://www.mdpi.com/2077-0383/9/2/523 https://www.mdpi.com/2077-0383/9/2/523 https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-2019-nCoV-severity-10-02-2020.pdf https://www.imperial.ac.uk/media/imperial-college/medicine/s... https://institutefordiseasemodeling.github.io/nCoV-public/analyses/first_adjusted_mortality_estimates_and_risk_assessment/2019-nCoV-preliminary_age_and_time_adjusted_mortality_rates_and_pandemic_risk_assessment.html https://institutefordiseasemodeling.github.io/nCoV-public/an... https://github.com/calthaus/ncov-cfr/blob/d30f02e1c20e06103aad6a04eb492dd156466d98/README.md https://github.com/calthaus/ncov-cfr/blob/d30f02e1c20e06103a... (3 of the 4 above studies are even referenced by the WHO in their Coronavirus disease situation report 30 (references 10, 11 and 12) and in situation report 31: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200219-sitrep-30-covid-19.pdf https://www.who.int/docs/default-source/coronaviruse/situati... and https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200220-sitrep-31-covid-19.pdf https://www.who.int/docs/default-source/coronaviruse/situati... ) And they all estimate the CFR to be between 0.5% and 1.6%, or about 5x to 16x deadlier than the flu (0.1%)

nodamage 7y ago
Thank you for sharing this. I keep seeing people try to claim "but we don't know the true number of unreported cases therefore the true CFR is lower than reported" as if epidemiologists are somehow unaware of this factor.

cbolton 7y ago

> > Expect people you know to die. > Aside from this likely being inaccurate, is this language even remotely helpful? If it is accurate I appreciate someone informing me in brief and plain terms.

miked85 7y ago

> Expect people you know to die. > There will be significant economic disruption > Daily life will be impacted in important ways > The acute pandemic will probably last at least for several months and quite possibly for a year or two. Agreed, this seems very sensationalist. Any or all of the above could be true, but at best, she is guessing right now.

gexla 7y ago

Right, it's still an unknown, which is why there's such a great concern. As I have said before, if you are going to make a bet, you need to know the odds. We don't know the odds yet. This also means that we can't be sure of any of these numbers. Maybe the correct way to think of this isn't "people you know will die" but rather "people you know may die, so we need to be paranoid and prepare."

inciampati 7y ago

Genomic estimates suggest that there may be several thousand infected individuals, maybe many thousand, in Washington state. But we are only aware of a small handful of them. One explanation for this would be that many people are completely asymptomatic, or can't distinguish COVID-19 from a very mild cold. That would be in line with the NEJM article you shared, and explain why there haven't been any cases in children. If they don't have a strong enough reaction to require treatment or testing then it would seem they don't even get infected under the metrics that are established. The major problem is systemic risk from many people requiring intensive care all at once. The author of the linked blog post didn't mention an important and unsettling feature of the Spanish flu. It came in three waves. The first looked very similar to a bad seasonal flu or the current SARS outbreak. The second was the one that killed, by inducing a cytokine storm and immune overreaction in otherwise healthy, younger people. Deaths sometimes occurred in a matter of hours after the first appearance symptoms. Having an incredibly infectious virus cause a pandemic is one thing. Let's hope that we can monitor it's evolution to ensure that strains that it develops aren't significantly more dangerous. Its infectivity means that it will have a massive environment in which to evolve. Evolution rate is largely determined by population size.

bakul 7y ago

Here is an interesting comparison of mortality rate by age for SARS-Cov-2, 1918 'flu and seasonal 'flu: https://raw.githubusercontent.com/jbloom/CoV_vs_flu_CFR/master/CFR-stats.jpg https://raw.githubusercontent.com/jbloom/CoV_vs_flu_CFR/mast... Some context: https://twitter.com/petrakle/status/1234587264904318978 https://twitter.com/petrakle/status/1234587264904318978 This is based on data published so far.

pbourke 7y ago

In addition to this piece, there is this interview with Harvard Epidemiologist Marc Lipsitch [1]: > Whatever the number is, it's gonna take a toll. If it really does spread as widely as that projection says, and that's what I think is likely to happen, then there are gonna be millions of people dying. And I don't think there's any way to get around that. And so I think there's real reason for people to be concerned. I also think that we can turn that concern into actions that will make the situation better. I think pieces like this and the linked interview with Marc Lipsitch, which are clear-eyed reads on the situation from experts, should break through to the general public so they can take some action. [1] https://www.cbsnews.com/news/coronavirus-infection-outbreak-worldwide-virus-expert-warning-today-2020-03-02/ https://www.cbsnews.com/news/coronavirus-infection-outbreak-...

brownbat 7y ago

Dr. Fauci's iceberg theory, that the cfr will decline as we identify more mild cases, is disputed by some in the WHO and some Chinese scientists, who argue the CFR is well supported from comprehensive testing of quarantined populations, which identify and account for mild and asymptomatic cases. One such study: http://www.cidrap.umn.edu/news-perspective/2020/02/study-72000-covid-19-patients-finds-23-death-rate http://www.cidrap.umn.edu/news-perspective/2020/02/study-720... While the specific r0 and cfr are still under debate, there's no doubt this has rapidly absorbed hospital resources in hotspots in ways other coronaviruses haven't. I don't think panic is the right answer, but people should prepare for the possibility this impacts their lives, judging from regions with cases and the continued spread to new regions. Quarantines, social distancing, fewer public activities, and extended hospitalizations of some older family members are all realistic scenarios.

notacoward 7y ago

> It sounds increasingly likely that the fatality rate is less than 1% If enough people get it badly enough to require significant medical care, that will quickly overwhelm hospitals, and the fatality rate among those turned away will be much higher. We're more likely to follow the Iran pattern (CFR = 5.5%) than that from Japan or South Korea or even China.

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