Here's the original article: High-dose vitamin C enhances cancer immunotherapy https://stm.sciencemag.org/content/12/532/eaay8707/ https://stm.sciencemag.org/c

Here's the original article: High-dose vitamin C enhances cancer immunotherapy https://stm.sciencemag.org/content/12/532/eaay8707/ https://stm.sciencemag.org/content/12/532/eaay8707/ Takeaways: Oral Vitamin C and intravenous Vitamin C have vastly different pharmacokinetics and effects on cancer. - Low dose vitamin C (oral) is anti-oxidant and may attenuate chemotherapy: Chemosensitizing effect of vitamin C in combination with 5-fluorouracil in vitro https://www.ncbi.nlm.nih.gov/pubmed/12929582 https://www.ncbi.nlm.nih.gov/pubmed/12929582 "only a high concentration of vitamin C increased the cytotoxicity of 5-FU" Ascorbic acid attenuates antineoplastic drug 5-fluorouracil induced gastrointestinal toxicity in rats by modulating the expression of inflammatory mediators https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598240/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598240/ - High dose vitamin C (intravenous) is pro-oxidant - High dose vitamin C (intravenous) alone slows tumor growth - High dose vitamin C (intravenous) combined with immunotherapy has a synergistic effect High dose vitamin C (intravenous) also synergizes with chemotherapy and spares healthy cells https://stm.sciencemag.org/content/6/222/222ra18 https://stm.sciencemag.org/content/6/222/222ra18 If you are in chemotherapy or immunotherapy, stay away from low doses of oral anti-oxidant supplements such as Vitamin C.