5 ms·

How can I find it out if I have high ACE2?

by pezo1919 7y ago

rolph 7y ago
having high ACE2 is not something that you need to worry about as you only need enough to get the virus in you. - having "high" ACE2 could actually be a benefit if it turns out that you retain proper ACE2 functionality after infection and through the course of the physiological challenge of the virus.
- seieste 7y ago
  This seems to be in contradiction of other published results. Can you provide a source?
  - rolph 7y ago
    could you please provide citations and the contradictions?
  - ptest1 7y ago
    As far as I can tell, there are no studies showing a higher ACE2 causes more severe disease. Sure, it could, but the pathophysiological models and animal data suggest that it is the loss of ACE2 that may drive disease severity. There is a contradictory preprint (that hasn’t passed peer review) on ACE2 mRNA expression in smokers’ lungs being higher than non-smokers; but there is data saying the opposite happens in animal models of mice exposed to smoke: https://pubmed.ncbi.nlm.nih.gov/20178811-losartan-attenuates-chronic-cigarette-smoke-exposure-induced-pulmonary-arterial-hypertension-in-rats-possible-involvement-of-angiotensin-converting-enzyme-2/ https://pubmed.ncbi.nlm.nih.gov/20178811-losartan-attenuates... There is also an inaccurate preprint on ethnic groups and ACE2 expression with a low n count which also didn’t pass peer review. ACE2 loss is probably bad, having more ACE2 probably doesn’t drive disease severity: https://twitter.com/__philipn__/status/1229568317167243264?s=21 https://twitter.com/__philipn__/status/1229568317167243264?s... Relative ace2 reduction correlates w disease severity; viral load growth the same between groups - check out study! Chinese paper discusses this as well: https://pubmed.ncbi.nlm.nih.gov/32061198-inhibitors-of-ras-might-be-a-good-choice-for-the-therapy-of-covid-19-pneumonia/?from_single_result=Inhibitors+of+RAS+covid https://pubmed.ncbi.nlm.nih.gov/32061198-inhibitors-of-ras-m...

How can I find it out if I have high ACE2?

having high ACE2 is not something that you need to worry about as you only need enough to get the virus in you. - having "high" ACE2 could actually be a benefit if it turns out that you retain proper ACE2 functionality after infection and through the course of the physiological challenge of the virus.

seieste 7y ago
This seems to be in contradiction of other published results. Can you provide a source?
- rolph 7y ago
  could you please provide citations and the contradictions?
- ptest1 7y ago
  As far as I can tell, there are no studies showing a higher ACE2 causes more severe disease. Sure, it could, but the pathophysiological models and animal data suggest that it is the loss of ACE2 that may drive disease severity. There is a contradictory preprint (that hasn’t passed peer review) on ACE2 mRNA expression in smokers’ lungs being higher than non-smokers; but there is data saying the opposite happens in animal models of mice exposed to smoke: https://pubmed.ncbi.nlm.nih.gov/20178811-losartan-attenuates-chronic-cigarette-smoke-exposure-induced-pulmonary-arterial-hypertension-in-rats-possible-involvement-of-angiotensin-converting-enzyme-2/ https://pubmed.ncbi.nlm.nih.gov/20178811-losartan-attenuates... There is also an inaccurate preprint on ethnic groups and ACE2 expression with a low n count which also didn’t pass peer review. ACE2 loss is probably bad, having more ACE2 probably doesn’t drive disease severity: https://twitter.com/__philipn__/status/1229568317167243264?s=21 https://twitter.com/__philipn__/status/1229568317167243264?s... Relative ace2 reduction correlates w disease severity; viral load growth the same between groups - check out study! Chinese paper discusses this as well: https://pubmed.ncbi.nlm.nih.gov/32061198-inhibitors-of-ras-might-be-a-good-choice-for-the-therapy-of-covid-19-pneumonia/?from_single_result=Inhibitors+of+RAS+covid https://pubmed.ncbi.nlm.nih.gov/32061198-inhibitors-of-ras-m...