Most importantly, a placebo controlled RCT would be unethical for a disease with high mortality rates. You would run a randomized controlled trial with treatme

Most importantly, a placebo controlled RCT would be unethical for a disease with high mortality rates. You would run a randomized controlled trial with treatment control (not placebo controlled) when we have an effective treatment. These are about as good as it is assumed placebo effects figure the same in all tested treatment groups.