The article describes negative effects of inflammation which persists long after the underlying condition has been addressed, due to persistently elevated level

The article describes negative effects of inflammation which persists long after the underlying condition has been addressed, due to persistently elevated levels of the HMGB1 protein. It notes that "anti-HMGB1 treatment given several days after a serious illness can reduce cognitive decline in mice" and proposing that these results might some day be replicated in humans.