The issue is that no pharma company wants to make drugs that will be carefully stewarded as last lines of defense vs super bugs. You won't see 3M patients per y

The issue is that no pharma company wants to make drugs that will be carefully stewarded as last lines of defense vs super bugs. You won't see 3M patients per year because every hospital system worth its salt has antimicrobial stewardship programs which will interrogate every case of antibiotic use. Doctors are trained and pushed into using these drugs as infrequently as possible because they all know Darwinian selective pressure will render antibiotics less useful the more they're used. But it's a different story in developing nations with lower standards, where they will steal your IP and bombard the microbial population with every antibiotic they can. Furthermore, agriculture will surely love to grab new compounds to blanket their herds with. They will not give pharma great profits either, and they'll increase resistance to your fancy new drug that you spent billions developing. So overall, it's a grim financial picture for pharma and antibiotics. They would prefer to make cancer drugs, chronic disease drugs, biologics, and not these carefully stewarded and easily ripped off antibiotics. IMO, antibiotics will come from altruistic scientists working on their own, and not from the CFOs and bottom lines of pharma.