Here is a prior HN submission that talks about the economics of new drug development for rare diseases: https://news.ycombinator.com/item?id=19787367 https://n

Here is a prior HN submission that talks about the economics of new drug development for rare diseases: https://news.ycombinator.com/item?id=19787367 https://news.ycombinator.com/item?id=19787367 tl;dr: a hypothetical drug with an expected profit of $547 million, adjusted for discounting and risk, has an expected value of negative $6 million.