3 ms·
It's worth reading the paper, which calls out its own limitations: * It is unknown if ACE2 is the only important receptor * Study doesn't actually count the a
by icegreentea2 7y ago
It's worth reading the paper, which calls out its own limitations:
* It is unknown if ACE2 is the only important receptor
* Study doesn't actually count the amount of ACE2 receptors, just the amount of RNA expression (ok, you can probably hand wave this limitation away)
* Study also shows a difference of expression ratio of 1.6% vs 0.4% in males vs females (n=2 vs n=6)
* There was a SINGLE asian male in the data set
Given these limitations of the original paper, at the very least, I would say that you should shy away from definitive statements until stronger evidence appears.
The top comment on biorxiv ran with some of the ideas from the paper, and looked at a more general and larger data set and found no statistically significant difference between Asian and Caucasian lung tissue samples in terms of ACE2 expression when measured in bulk (see https://uploads.disquscdn.com/images/5cb4b2c5e1ae3cf8454e870f139b03b987614b28052f899aec0ee160c32ff548.png https://uploads.disquscdn.com/images/5cb4b2c5e1ae3cf8454e870...)
That said, it's certainly a cool paper.
- Qu3tzal 7y ago> (n=2 vs n=6) * There was a SINGLE asian male in the data set From my understanding of statistics and biology this is not significant at all then.
- chrisco255 7y agoFrom that link above, "there are eight and 436 putative Asians and Caucasians, respectively (imputed from the first two principal components" so its comparing a sample size of 8 Asians with a sample size of 436 Caucasians. I'd say the jury is still out on whether there is a racial difference in ACE2 expression, but good call out either way.