For me the sweet spot is a triple monitor setup with all three monitors in the neighborhood of 200 DPI, and running at 200% scaling in either Windows or Linux (

For me the sweet spot is a triple monitor setup with all three monitors in the neighborhood of 200 DPI, and running at 200% scaling in either Windows or Linux (Cinnamon). One monitor is my ThinkPad's 14" WQHD display. The other two are 24" 4K displays. One of those displays is horizontal, immediately above the ThinkPad display. The other is vertical, to the left, with the bottom of the monitor close to my standing desk. (Of course it could be on the right if that suits you better.) Because I'm old enough that my eyes can not adjust their focus like a younger person's eyes, I make sure that all three monitors are at the same distance from my eyes. And I have a pair of single vision prescription glasses adjusted for that distance. Since I also use the ThinkPad on its own, that determines the focus distance: about 20 inches. The external monitors are also at that distance from my eyes. Each of the three monitors is tilted at the appropriate angle so that the plane of the monitor is perpendicular to the view from my eye position. In other words, the "normal" at the center of each monitor points directly to my eyes. I can't use big monitors like a 32", regardless of the resolution. The focus distance changes too much between the center of the monitor and its edges. But 24" is small enough that the entire monitor is in focus with my single vision glasses. Did I mention single vision glasses?! Unless you are young enough that your eyes can easily refocus, do yourself a favor and get these. Not a "reading" prescription - that is typically 16", much too close for typical computer use. Bring your laptop to your optometrist and get single vision lenses for that distance. It will probably be about 20". Then when you use external monitors, make sure they are also at that same distance. Do not under any circumstances use progressive lenses for computer work! I have seen far too many people tilt their head back and lower their gaze into the bottom part of their progressives. This is a recipe for neck and eye strain. You will be amazed at the improvement that a good pair of single vision lenses give you.