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Thank you for posting. This is a huge problem. The FDA is under regulatory capture by the pharmaceutical and medical device industries. Contrary to what many be
by doitLP 7y ago
Thank you for posting. This is a huge problem. The FDA is under regulatory capture by the pharmaceutical and medical device industries. Contrary to what many believe, a lot of drug studies never see the light of day, if they show null or negative results. And decades go by with companies knowing but not publishing about certain side effects.
There are a lot of great people in this industry but the incentives are often so horribly misaligned against consumers’ best interests that it is shocking.
- mft_ 7y agoYou're right that the industry should do better than it does, but the evidence shows that non-industry sponsors are actually worse at compliance with these reporting rules, than industry sponsors. [0] [0] https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)33220-9/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
- doitLP 7y agoSure but who does most of the research, especially of new drug/compounds?
- refurb 7y agoIndustry does. Industry R&D spend is almost double that of gov’t spend. Academia does most of the basic science.
- mft_ 7y agoAccording to Goldacre et al [0] from the 4209 trials included in their analysis, 2178 (51.8%) were non-industry, 1837 (43·6%) were sponsored by industry, and 194 (4·6%) were sponsored by the US Government. So a (modest) majority were sponsored by non-industry. [0] https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)33220-9/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
- refurb 7y agoProblem is that publishing a trial that fails doesn’t get you tenure.