Fascinating. I mean we know that repetitive TMS can induce mania in unipolar depression cases so it makes sense that Surmount could have a manic psychosis indu

Fascinating. I mean we know that repetitive TMS can induce mania in unipolar depression cases so it makes sense that Surmount could have a manic psychosis induced by it. I think the trigger rate is higher for bipolar patients as well. And while it's rare in general, Surmount had a lot of treatments which probably raised the likelihood of a manic episode. I don't think we know the combined effect of TMS and antidepressants for example and the likelihood they trigger mania.