3 ms·
Amyloid plaques are clearly not the problem, but I thought we already knew that? When did these experiments get launched? There are people who appear to be ge
by eternalny1 7y ago
Amyloid plaques are clearly not the problem, but I thought we already knew that? When did these experiments get launched?
There are people who appear to be genetically immune to Alzheimer's yet build up massive amyloid plaques. They do not show any symptoms of the disease, so shouldn't this have been ruled out by now?
- jcranmer 7y agoLooking back through Derek Lowe's posts, I don't think he considered the amyloid hypothesis dead until around 2016 or so. The study was started in December 2012, according the clinicaltrials.gov posting. At that time, you had the first round of amyloid blockers that didn't work, but you were in the midst of the hail-mary round of "maybe it works if you catch it early/in this group of people/etc." tests. Indeed, this is one of those studies.