> I really don’t know what else to say at this point. I’ve been writing this blog since 2002, several years after my own experiences with Alzheimer’s drug disco

> I really don’t know what else to say at this point. I’ve been writing this blog since 2002, several years after my own experiences with Alzheimer’s drug discovery, and ever since then I have chronicled the failure of drug after drug aimed at the amyloid hypothesis. Different mechanisms, different dosing, different patient populations, different trial designs: none of it has worked. Not once. I myself include the most recent Biogen/Eisai antibody efforts in that list – yes, the one that they’ve submitted to the FDA and are trying to get approved, a decision about which I have made my position abundantly clear. What's remarkable isn't the failure of this trial, but the complete lack of efficacy for any drug working through the "amyloid hypothesis." https://en.wikipedia.org/wiki/Biochemistry_of_Alzheimer%27s_disease#Amyloid_hypothesis https://en.wikipedia.org/wiki/Biochemistry_of_Alzheimer%27s_... Either this hypothesis is completely wrong, or all of the drugs in all of these trials aren't able to address the amyloid. Given the weight of evidence, it seems like there's not much left of the amyloid hypothesis to even poke a hole through.