> The data shows that reducing amyloid-beta load is not sufficient to confer a clinical benefit. No, this trial was designed to test whether preventing amyloid

> The data shows that reducing amyloid-beta load is not sufficient to confer a clinical benefit. No, this trial was designed to test whether preventing amyloid plaque formation can prevent Alzheimer's. To the extent that it does not (which appears to be the conclusion), then it's safe to say that amyloid hypothesis is wrong. In other words, if these patients do not acquire amyloid plaque, but still acquire Alzheimer's at the same rate and severity, then amyloid plaques logically cannot be the cause of Alzheimer's. This should no longer surprise anyone. These studies, coupled with the existence of people who have been found to be loaded with amyloid plaque and yet do NOT get Alzheimers [1], should be plenty to change the direction of research. 1 - https://www.sciencemag.org/news/2019/11/colombian-woman-s-genes-offer-new-clues-staving-alzheimer-s https://www.sciencemag.org/news/2019/11/colombian-woman-s-ge...