Sorry to hear about your experiences with Alzheimers. That gene, presenilin 2, is part of the amyloid processing complex and plays a role in the amyloid hypoth

Sorry to hear about your experiences with Alzheimers. That gene, presenilin 2, is part of the amyloid processing complex and plays a role in the amyloid hypothesis (which is highlighted by the news article and the paper itself, https://science.sciencemag.org/content/269/5226/970, https://science.sciencemag.org/content/269/5226/970,) meaning that the very study that this hacker news thread is about, as well as hundreds of other studies and trials, are all investigating this hypothesis. Unfortunately, while the article you've linked says that this discovery helped "solve the mystery of early onset AD," it so turns out that the proposhed mechanism did not live up to scrutiny. Could this protein have different effects (such as a role in calcium ion leakage as later papers suggest)? Perhaps, and it might prove a crucial part of treating alzheimers in the long run, but it doesn't look like that research was in any way overlooked. Research is hard, it's only been a couple decades since new potential mechanisms of action of that gene were identified, and this is a complex disease, but the needle is moving.