ON the other hand, those methods of collecting large amounts of high quality data might only seem promising because they're effectively just ways to run thousan

ON the other hand, those methods of collecting large amounts of high quality data might only seem promising because they're effectively just ways to run thousands or millions of gels at once before picking out the ones that "look right." The fundamental incentives to not publish null results and to publish or perish haven't disappeared. It's not that people aren't capable of running high quality, reproducible experiments, or that the tools aren't there, it's just that people need to publish to advance in their careers. These new high throughput screens get your quick publications and let you overfit models to the data you collect, and it might seem like a transformation now, but if people weren't incentivized to spend a couple hundred bucks to replicate a gel in the past, do you think they'll actually be incentivized to spend thousands of dollars and computation time to try and replicate screens and the models derived from them?