In general, Yes this is a big issue when dealing with colors. One example where you run into this; is when you'r reducing color space from say 256 to say 12 co

In general, Yes this is a big issue when dealing with colors. One example where you run into this; is when you'r reducing color space from say 256 to say 12 color space (most common colors). Using LAB really helps but still not perfect.