5 ms·
Great article all around, worth reading as it's one of the only I've seen that are actually talking about disease progression and timeline. Some key info from t
by forgingahead 7y ago
Great article all around, worth reading as it's one of the only I've seen that are actually talking about disease progression and timeline. Some key info from the article:
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Caixin: Based on your clinical experience, what's the disease progression of the new coronavirus?
Peng: Lately I've been spending the daytime seeing patients in the ICU, then doing some research in the evenings. I just wrote a thesis. I drew on data from 138 cases that South Central Hospital had from Jan 7 to Jan 28 and attempted to summarise some patterns of the novel coronavirus.
A lot of viruses will die off on their own after a certain amount of time. We call these self-limited diseases.
I've observed that the breakout period of the novel coronavirus tends to be three weeks, from the onset of symptoms to developing difficulties breathing. Basically going from mild to severe symptoms takes about a week. There are all sorts of mild symptoms: feebleness, shortness of breath, some people have fevers, some don't. Based on studies of our 138 cases, the most common symptoms in the first stage are fever (98.6 per cent of cases), feebleness (69.6 per cent), cough (59.4 per cent), muscle pains (34.8 per cent), difficulties breathing (31.2%), while less common symptoms include headaches, dizziness, stomach pain, diarrhea, nausea, vomiting.
But some patients who enter the second week will suddenly get worse. At this stage, people should go to the hospital. The elderly with underlying conditions may develop complications; some may need machine-assisted respiration. When the body's other organs start to fail, that's when it becomes severe, while those with strong immune systems see their symptoms decrease in severity at this stage and gradually recover. So the second week is what determines whether the illness becomes critical.
The third week determines whether critical illness leads to death. Some in critical condition who receive treatment can raise their level of lymphocytes, a type of white blood cell, and see an improvement in their immune systems, and have been brought back, so to speak. But those whose lymphocyte numbers continue to decline, those whose immune systems are destroyed in the end, experience multiple organ failure and die.
For most, the illness is over in two weeks, whereas for those for whom the illness becomes severe, if they can survive three weeks, they're good. Those that can't will die in three weeks.
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Whole thing is worth reading.
- not_a_moth 7y agoShould add their discussion of cytokine storms in healthy people, which appears to have a more rapid timeline > Some experts argue that the virus triggers a cytokine storm, which ravages the stronger immune system of young adults > Based on my observations, a third of patients exhibited inflammation in their whole body. It was not necessarily limited to young adults. The mechanism of a cytokine storm is about whole-body inflammation, which leads to a failure of multiple organs and quickly evolves into the terminal stage. In some fast-progressing cases, it took two to three days to progress from whole-body inflammation to the life-threatening stage.
- oxymoran 7y agoLook, you say inflammatory response science says steroids. But what about CBD? Maybe even THC? Let’s experiment at least,
- topmonk 7y agoI always found a shot of straight whisky was good for a cold.
- faeyanpiraat 7y ago60% of the time, it works every time.
- sterlind 7y agothe 1918 flu pandemic caused a cytokine storm, which is hypothesized to have caused so many otherwise healthy people to die. if there's cytokine activity that's another parallel to the Spanish flu.
- fspeech 7y agoThe cases that the interview alluded to have already been published in JAMA: Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China https://jamanetwork.com/journals/jama/fullarticle/2761044 https://jamanetwork.com/journals/jama/fullarticle/2761044 Note Dr. Peng in the interview is one of the authors of the JAMA article.
- yread 7y agoI find it so strange that even people who should know better say yeah there is 30k cases and 600 deaths so only 2% die. They should look at the clinical progression of the disease, if it takes 2 weeks from hospitalization to death - how many cases where there 2 weeks ago: those were the people that died.
- hef19898 7y agoYeah, and people who know better say anything different than that? Or what exactly don't you like about official WHO numbers based on global data that pretty much alines with Chinese ones? EDIT: What makes you think highly educated people just doing epidemics didn't have that ideas alrwady and didn't base their numbers on that?