Source? Because this suggests the opposite: https://journals.physiology.org/doi/abs/10.1152/ajpregu.00099.2018 https://journals.physiology.org/doi/abs/10.1152/

Source? Because this suggests the opposite: https://journals.physiology.org/doi/abs/10.1152/ajpregu.00099.2018 https://journals.physiology.org/doi/abs/10.1152/ajpregu.0009... "The literature presented in this review strongly suggests that nicotine alters the homeostasis of the RAS by ... downregulating the compensatory ACE2/ANG-(1–7)/Mas receptor axis." "In primary cultures of neurons and glial cells isolated from brainstem and hypothalamus of 1-day-old rats, nicotine treatment resulted in increased expression of AT 1 R but decreased expression of ACE2."