I think we all underestimate how far apart just solar systems are. In the common projections we take a travel speed of 1-10% speed of light for granted which is

I think we all underestimate how far apart just solar systems are. In the common projections we take a travel speed of 1-10% speed of light for granted which is insanely hard to achieve with any significant mass. If we indeed make it out of our solar system (and not just once), mankind will eventually spread all over the Milky Way. Anyway, to come back to your point: Looking at https://en.wikipedia.org/wiki/List_of_nearest_galaxies https://en.wikipedia.org/wiki/List_of_nearest_galaxies we would start with satellite galaxies, the closest one is 25.000 light years away. Unthinkable for now.