Nice work, very comprehensive， ‘A’ for effort, good for citing in reviews. The results are well known from other studies (eg sequencing cancer precursor lesions

Nice work, very comprehensive， ‘A’ for effort, good for citing in reviews. The results are well known from other studies (eg sequencing cancer precursor lesions) and theoretical predictions over 40 years old. They try to elevate the significance by saying the results could be useful in early detection, but the companies doing early detection through circulating tumour DNA have already moved on from looking at mutations to methylation and other epigenetic changes.