TLDR • 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. • Mice exposed to a dose penetrated through the b

TLDR • 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. • Mice exposed to a dose penetrated through the bare filter showed rapid body weight loss, followed by death within 10 days after infection • (PP) microfiber filter, was coated with NaCl salt as an active virus negation unit • The coating formulations contained surfactant to enhance wetting of saline solution on the surface of hydrophobic PP fibers • The coating solution was prepared by dissolving sodium chloride NaCl in filtered DI water under stirring at 400 rpm and 90 °C, followed by the addition of Tween 20 to a final concentration of 29.03 w/v% of NaCl and 1 v/v% of Tween 20. • the mask bare PP filters were pre-wet to contain approximately 600 μL of coating solution by incubating overnight at room temperature. Any remaining dry areas were removed by applying gentle strokes with tweezers to the filters while immersed in the coating solution. Subsequently, the filters were deposited in the desired volume of coating solution (0, 100, 300, 600, 900 and 1200 μL, of which corresponding membranes are abbreviated as Filterwet, Filterwet+100μL, Filterwet+300μL, Filterwet+600μL, Filterwet+900μL, and Filterwet+1200μL, respectively) on petri dishes (60 × 15 mm; Fisher Scientific) to control the amount of NaCl per unit area and dried in an oven (Isotemp Incubator, Fisher Scientific) at 37 °C for 1 day.