Fedora Silverblue and Endless OS do this, they're both based off of OSTree for treating filesystem-as-image and expect software to be run in Flatpak or OCI (Doc

Fedora Silverblue and Endless OS do this, they're both based off of OSTree for treating filesystem-as-image and expect software to be run in Flatpak or OCI (Docker) containers. There's some rough edges in Silverblue at least, but its a neat way to work.