> Not lung cancer per se; the paper focuses only on reversal of tumor mutation burden of the cells that line the lungs and airways. The main cause of lung canc

> Not lung cancer per se; the paper focuses only on reversal of tumor mutation burden of the cells that line the lungs and airways. The main cause of lung cancer is precisely that mutation burden that the paper studies. From what I read, most lung cancers stem from mutations of bronchial epithelial cells instead of mutations in the alveoles or other parts of the lung. The mutation burden is both the cause of lung cancer and can advance the disease by further mutations leading to accelerated growth/metasthazing behaviour/etc.