Thanks for the link. The guarantees they present in that article seem a lot stronger than the HN submission. They explain what they intend by "self limiting" a

Thanks for the link. The guarantees they present in that article seem a lot stronger than the HN submission. They explain what they intend by "self limiting" and then it turns out that it doesn't work anyway (with a 4% survival rate of Female carriers in the wild). In the HN submission (a later experiment) they don't seem to be anywhere near as careful. They just say it's "self limiting" but that the genes are passed onto offspring (of which, the males survive). I'm not an expert in genetic biology and my differential calculus is rusty but, intuitively, I'd expect that if you had even a small percentage of matings that didn't produce Female offspring then the overall proportion of males would rise. It's not immediately clear what the equilibrium point of male carriers would be. ...so how does it "self limit" in the case where the limit is not merely "all (female) moths have died"? Do all males end up infected? What is the range of these moths? Can they fly to other places and gradually spread out over a geography? I have so many questions and, to a non-expert, it all sounds rather scary!