> First, have you seen clear, lasting changes in anxiety and depression? If the single-dose effect for cancer patients really is this strong, it seems like ever

> First, have you seen clear, lasting changes in anxiety and depression? If the single-dose effect for cancer patients really is this strong, it seems like everyone who messed with mushrooms once in college should be 'treated' also. I think mushrooms can open the door, but you need to use them as a catalyst to take action in your day-to-day life to actually have lasting change. I've still been an asshole occasionally since taking mushrooms. Ultimately you're responsible for your own change, but mushrooms can help you want to change. > Second, how well do those feelings of contentment stick around? The stories I hear of enlightenment on mushrooms, DMT, any other "entheogen" all have the element you describe of being unable to grasp the discovery after the trip, and once it's in hindsight I can imagine that memory being anywhere from comforting to aggravatingly out-of-reach. I've had an egoless state for a couple hours or so afterwards, and then maybe for a couple days afterwards I'm generally more relaxed and happy: maybe I'll smile more and say hello to people I barely talk to. But the feeling fades after that. Lasting change happens if you really take the lesson to heart and create change in your normal life.