4 ms·
The very first nCoV genome sequencied earlier this month[0] ends with 33 As, while the genome of the virus found in the first U.S. patient[1] ends with only 12
by voldacar 7y ago
The very first nCoV genome sequencied earlier this month[0] ends with 33 As, while the genome of the virus found in the first U.S. patient[1] ends with only 12 As.
Is it normal for there to be variation here? Do these repeated A sequences actually code for a protein or are they just a marker to let the ribosome know it's reached the end of the genome, and so the length of repeating As doesn't really matter past a certain point?
(I'm obviously not a biologist)
[0]https://www.ncbi.nlm.nih.gov/nuccore/MN908947 https://www.ncbi.nlm.nih.gov/nuccore/MN908947
[1]https://www.ncbi.nlm.nih.gov/nuccore/MN985325 https://www.ncbi.nlm.nih.gov/nuccore/MN985325
- deleted 7y ago[deleted]
- CrazyStat 7y agoOne of the papers mentioned in the linked discussion shows that the number of As can vary over time within a single patient. There seems to be some evidence that different lengths might give an advantage or disadvantage in replication, but it seems like variation is normal. (also not a biologist, though I work with some)