5 ms·
The most complete brain map: a fly's 'connectome'
- MrsPeaches 7y agoFor anyone with an interest in this field, I would highly recommend Vehicles by Valentino Braiteberg. [1] A very nice intro into how these structures could give rise to actual behaviours. [1] https://www.goodreads.com/book/show/483485.Vehicles https://www.goodreads.com/book/show/483485.Vehicles
- allovernow 7y agoThat's awesome but...where are the images???
- kwelstr 7y agohttps://www.janelia.org/project-team/flyem/hemibrain https://www.janelia.org/project-team/flyem/hemibrain
- gdubs 7y agoThanks for providing the link — these are stunning. Like a generative art piece.
- davidwihl 7y agoSee also https://ai.googleblog.com/2019/08/an-interactive-automated-3d.html https://ai.googleblog.com/2019/08/an-interactive-automated-3...
- alcover 7y agoTo view the pictures you have to let this.. thing load 40 (forty) scripts. Screw it. I won't view the pictures.
- The_mboga_real 7y ago40 million and 12 years of hard work. Connecting the dots!
- deleted 7y ago[deleted]
- lloda 7y agoSo, how far are we from a fly simulation that works?
- npo9 7y agoThis is theoretically all the data about a flys nervous system, which would be the hardest data collection part of building a fly simulation.
- GitRHero 7y agoThis seems to be more simply all the data about the physical orientations and positions of neurons in a fly's nervous system. I'd guess there is still humongous amounts of data missing that would be necessary for a simulation: - the exact biological and chemical makeup of each neuron - the biological and chemical environment in which those neurons exist - the exact physics that govern the biological and chemical reactions happening in and around the neurons (and the ability to accurately simulate those physics) - maybe most importantly, even if we have all those above (i.e. the ability to fully and accurately simulate biological systems as complex as individual cells), we may still missing the electro-chemical activation "state" of the neurons that allows the fly to operate as a cohesive whole. (as if we had all of the hardware of a computer, but none of the software)
- falcor84 7y agoThe GP asked about "a fly simulation that works", and I think we won't need anything similar to your proposed demands. I'd wager that we can approach this decently well with a "basic" mathematical model run at discrete steps on the order of 0.1ms. I suppose that we'll hit a big wall once we reach simulation time frames which involves changes in protein expression, but I think we'll have a decent simulation of what a "static" fly long before the end of the decade.
- tsimionescu 7y agoIf the model has no data on the neuro-chemistry of the fly brain, why would you think it is even remotely close to simulating the behavior of the fly?
- fnord77 7y agoWould this map of neuronal connections be the same on all fruit flies of that species? Or does it vary between individuals?
- refurb 7y agoI’d be shocked if there wasn’t some variation across individuals, but suspect that at a high level, the major structures are the same.
- fnord77 7y agocorrect me if I'm wrong, but I thought this map isn't at the high level. It is a map of every single neuron connection for this region of the fly's brain. As low-level as it gets.
- refurb 7y agoSure. But the question was - is every brain the same. I would say it’s similar, but not identical. Kind of like the first human genome sequenced. It’s just one humans DNA, but any give human has very similar DNA. Small differences matter greatly though.
- martythemaniak 7y agoI highly recommend this lecture by Jeff Lichtman, where he describes the machine they've built to slice the brain and the software they have written to visualize and make sense of this vast amount of data: https://www.youtube.com/watch?v=2QVy0n_rdBI https://www.youtube.com/watch?v=2QVy0n_rdBI
- appleflaxen 7y agowhat software is being used for the 3d reconstruction and visualization? The images used to make the movie are incredibly impressive.