Efficiency is measured in a lot of different ways. Development speed? Team familiarity? Existing infrastructure (private pypi etc...)? Existing libraries? If w

Efficiency is measured in a lot of different ways. Development speed? Team familiarity? Existing infrastructure (private pypi etc...)? Existing libraries? If we go with what I would assume is your definition -- speed of execution versus resources used -- it is certainly possible to build fast Python applications that are efficient. But use what makes you and your team happy, life is too short for anything else.