I used to be able to run Matlab on FreeBSD(linux only since ~2016), so that made it much more desktop friendly as far as I was concerned. Currently OpenBSD can

I used to be able to run Matlab on FreeBSD(linux only since ~2016), so that made it much more desktop friendly as far as I was concerned. Currently OpenBSD can't run Wine and doesn't have any Linux compatibility layer. NetBSD had a youngin work on fixing Wine, but that hasn't been merged in to a release.