Yes I use AviSynth and AvsPMod all the time under Wine. I use the Avisynth+ 64 bit version and it works great, QTGMC and even SVP with OpenCL acceleration work

Yes I use AviSynth and AvsPMod all the time under Wine. I use the Avisynth+ 64 bit version and it works great, QTGMC and even SVP with OpenCL acceleration work fine. I can give you my wine prefix if you want. However like the sibling says, if you're doing something automated I'd recommend just using VapourSynth. QTGMC was ported to it ages ago and it will work better. I only continue to use AviSynth because the AvsPMod interface is still much better than the VSEdit equivalent, IMO.