3 ms·
> The findings, published in Nature Immunology, have not been tested in patients, but the researchers say they have "enormous potential". then later: > Howeve
by aazaa 7y ago
> The findings, published in Nature Immunology, have not been tested in patients, but the researchers say they have "enormous potential".
then later:
> However, the research has been tested only in animals and on cells in the laboratory, and more safety checks would be needed before human trials could start.
The abstract for the original article notes:
> ... An MR1-restricted T cell clone mediated in vivo regression of leukemia and conferred enhanced survival of NSG mice. TCR transfer to T cells of patients enabled killing of autologous and nonautologous melanoma. ...
https://www.nature.com/articles/s41590-019-0578-8 https://www.nature.com/articles/s41590-019-0578-8
What does that second sentence mean?
- acqq 7y ago“ Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.[1]” (from Wikipedia) “autologous - adjective - (of cells or tissues) obtained from the same individual.”
- acqq 7y agoAlso: TCR == T cell receptor Here are some the descriptions of the related methods currently researched: https://www.cancerresearch.org/immunotherapy/treatment-types/adoptive-cell-therapy#tcr https://www.cancerresearch.org/immunotherapy/treatment-types...