3 ms·
> I already got my DNA sequenced, but now that methylation can be measured cheaply as well, I don't see a reason why not to. Are they just quantifying how man
by arrosenberg 7y ago
> I already got my DNA sequenced, but now that methylation can be measured cheaply as well, I don't see a reason why not to.
Are they just quantifying how many methyl groups are attached to a piece of DNA? Methylation is a mechanism for site-specific in/activation, so I'm unclear (and curious) how this would be useful.
- xiphias2 7y agoMethylation is changes slowly throughout the life, the strongest predictor of age inside the body (that's why it's used as an aging clock). This also means that it may be the most important thing to learn to manipulate to defeat aging. Also it's the cause of many non-genetic chronic diseases that come with age. In summary it's a really really important thing to study. https://en.wikipedia.org/wiki/Epigenetic_clock#Properties_of_Horvath's_clock https://en.wikipedia.org/wiki/Epigenetic_clock#Properties_of... There are other hallmarks of aging though: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/