Depends on your values and your expectations. If you do time discounting, you can save more lives sooner by donating to VillageReach or the Stop TB Partnership

Depends on your values and your expectations. If you do time discounting, you can save more lives sooner by donating to VillageReach or the Stop TB Partnership. If you think human civilization might have some trouble negotiation the next few thousand years, an existential risk reduction charity like FHI or SIAI might be better. If neither of those applies, and you think SENS has a good chance of achieving their goal with sufficient funding, go for it!