4 ms·
You hit the nail on the head. The tech needs to be extended more than a week without massive necrosis (which occurred in 4/10 livers in the study). I think that
by epmaybe 7y ago
You hit the nail on the head. The tech needs to be extended more than a week without massive necrosis (which occurred in 4/10 livers in the study). I think that's something the authors of the Nature paper needed to have measured more of continuously (on top of the ATP production, BUN clearance, etc). Not sure which markers, to be honest, but there should be a decent range of apoptotic factors that can be sampled.
- JulianMorrison 7y agoI wonder if they could just break the liver up into pieces, junk the 4/10 pieces that went oogy, keep and merge the rest?
- cstejerean 7y agoApparently at least 25% of the liver is needed to regenerate into a whole liver. So at most you could break it up into 4 pieces (or maybe 3 to be on the safe side).