3 ms·

Just use a latest generation SSRI. Works for most people, minimal side effects. People take SSRIs for less, really. If you don't have PE though it makes you ano

Just use a latest generation SSRI. Works for most people, minimal side effects. People take SSRIs for less, really. If you don't have PE though it makes you anorgasmic.

questionfor 7y ago
Can you name any of the latest generation SSRI? Would taking them in this case make sense if there is no depression etc. Not seeking medical advice just want some perspective
- hndamien 7y ago
  MDMA works too, and improves just about everything else about the experience.
- dkarras 7y ago
  I was thinking about this: https://news.ycombinator.com/item?id=22030051 https://news.ycombinator.com/item?id=22030051 Of course you must consult to a doctor, but I've heard them writing those for PE. Edit: Also found this: https://www.ncbi.nlm.nih.gov/pubmed/17873675 https://www.ncbi.nlm.nih.gov/pubmed/17873675
oxide 7y ago
SSRI's give me ED. Doesn't matter how long I can go if I can't get the show started.
- dkarras 7y ago
  Which one? I was talking about something like citalopram / escitalopram which is very highly selective. Though I know that ED is a possible side effect even for escitalopram.
  - zaroth 7y ago
    60mg Dapoxetine, chosen for its extremely short half-life. Often combined in a single tablet with 100mg of Sildenafil. Take 1 hour before if possible. The Sildenafil kicks in before the Dapoxetine reaches peak absorption. Double-blind cross over with placebo confirms a significant effect (~2x duration). You may find you cannot ejaculate at all at that dose, and end up taking half a pill. Or you take the full dose on occasion and go for as long as your partner desires.
    - dkarras 7y ago
      I have the opposite problem unfortunately. I already could go however long I wanted (and sometimes longer) but on an SSRI I can't ejaculate at all (sometimes not even by myself) despite having stronger and easier erections. Otherwise the benefit is there so I'm keeping at it. Do you have something for that too?
      - zaroth 7y ago
        I’m not an expert on this, but you might find this interesting; https://www.issm.info/news/sex-health-headlines/cabergoline-for-treatment-of-male-anorgasmia/ https://www.issm.info/news/sex-health-headlines/cabergoline-... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822480/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822480/
ryan_j_naughton 7y ago
This suggestion sounds totally crazy to me. Yes, go ahead and profoundly impact your brain chemistry. There is emerging research indicating there could be serious long term effects of SSRIs for a significant percentage of the population. And there are definitely lots of side effects. Taking them for this seems crazy. Why not instead have an orgasm and then pleasure your partner until you can get erect again, at which point your will have more stamina. Or make sure to masturbate before your date. There are solutions that are way less invasive than SSRIs.

Just use a latest generation SSRI. Works for most people, minimal side effects. People take SSRIs for less, really. If you don't have PE though it makes you anorgasmic.

questionfor 7y ago

Can you name any of the latest generation SSRI? Would taking them in this case make sense if there is no depression etc. Not seeking medical advice just want some perspective

hndamien 7y ago
MDMA works too, and improves just about everything else about the experience.
dkarras 7y ago
I was thinking about this: https://news.ycombinator.com/item?id=22030051 https://news.ycombinator.com/item?id=22030051 Of course you must consult to a doctor, but I've heard them writing those for PE. Edit: Also found this: https://www.ncbi.nlm.nih.gov/pubmed/17873675 https://www.ncbi.nlm.nih.gov/pubmed/17873675

oxide 7y ago

SSRI's give me ED. Doesn't matter how long I can go if I can't get the show started.

dkarras 7y ago
Which one? I was talking about something like citalopram / escitalopram which is very highly selective. Though I know that ED is a possible side effect even for escitalopram.
- zaroth 7y ago
  60mg Dapoxetine, chosen for its extremely short half-life. Often combined in a single tablet with 100mg of Sildenafil. Take 1 hour before if possible. The Sildenafil kicks in before the Dapoxetine reaches peak absorption. Double-blind cross over with placebo confirms a significant effect (~2x duration). You may find you cannot ejaculate at all at that dose, and end up taking half a pill. Or you take the full dose on occasion and go for as long as your partner desires.
  - dkarras 7y ago
    I have the opposite problem unfortunately. I already could go however long I wanted (and sometimes longer) but on an SSRI I can't ejaculate at all (sometimes not even by myself) despite having stronger and easier erections. Otherwise the benefit is there so I'm keeping at it. Do you have something for that too?
    - zaroth 7y ago
      I’m not an expert on this, but you might find this interesting; https://www.issm.info/news/sex-health-headlines/cabergoline-for-treatment-of-male-anorgasmia/ https://www.issm.info/news/sex-health-headlines/cabergoline-... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822480/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822480/

ryan_j_naughton 7y ago

This suggestion sounds totally crazy to me. Yes, go ahead and profoundly impact your brain chemistry. There is emerging research indicating there could be serious long term effects of SSRIs for a significant percentage of the population. And there are definitely lots of side effects. Taking them for this seems crazy. Why not instead have an orgasm and then pleasure your partner until you can get erect again, at which point your will have more stamina. Or make sure to masturbate before your date. There are solutions that are way less invasive than SSRIs.