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If you add nitrite to ranitidine and heat it to 140 the levels of NDMA produced become carcinogenic. The person who made the discovery has a business built arou

If you add nitrite to ranitidine and heat it to 140 the levels of NDMA produced become carcinogenic. The person who made the discovery has a business built around consumer fear about contaminated pharmaceuticals.

endothrowho333 7y ago
Yes, it looks pretty obvious that V@lisure is running a scare campaign to boost traffic towards their services. I wonder if there's another play at hand here, though. Did they get in a spat with suppliers? Are they trying to dump the price of ranitidine and nizatidine to buy up at markedly reduced value? Perhaps drive down demand from drugs with less margins towards higher ones? For those downvoting: this is business as usual in entrenched markets like pharmaceuticals -- especially since the FDA has no capacity to enforce anything. And on more thorough review, it looks like the hysteria has spread to many other countries as well -- how quaint. For those that really aren't aware of what good hysteria marketing looks like, please take a look at: https://www.valisure.com/blog/uncategorized/detection-of-ndma-in-raniditine/ https://www.valisure.com/blog/uncategorized/detection-of-ndm... Anyone that works in the world of marketing/PR can see it plainly. I don't feel like digging into what strings they had to pull in order to get this viral, but anyone possessed by curiosity should take a look at their team: https://www.valisure.com/about-us/ https://www.valisure.com/about-us/ After reading their profiles, two members should instantly pop out at you.
- deeceejhay 7y ago
  Which two members' profiles? I didn't immediately see something.
  - endothrowho333 7y ago
    Cunningham and Gortler top out at MVPs -- if you base off their bios alone. Jirstrand is runner-up from all the impressive PR work she's done. Berkal: very weak maybe.
victor9000 7y ago
> Valisure also conducted tests with simulated gastric fluid (at body temperature, 37 degrees Celsius) and added sodium nitrite, simulating a diet with high levels of the common preservative found in processed meats, and found high levels of NDMA
- endothrowho333 7y ago
  See page 7: https://www.valisure.com/wp-content/uploads/Valisure-Ranitidine-FDA-Citizen-Petition-v4.12.pdf https://www.valisure.com/wp-content/uploads/Valisure-Ranitid... They did NOT simulate a normal diet with common levels of sodium nitrate. At 10 mM there is no NDMA found. Sodium nitrate concentrations for meat are much lower than 10 mM. The FDA puts a strict upper limit of sodium nitrate concentrations in meat at 100mg/kg, so around a concentration of .015mM (!) I don't need to do any further math to tell you no one is eating that much cured meat in a single sitting (it's simply not possible).
- CrazyStat 7y ago
  Not very helpful with knowing how much sodium nitrite they added. Are they simulating the diet of someone who eats a bologna sandwich for lunch every day, or the diet of someone who eats nothing but twenty pounds of straight bologna every day? Edit: sibling comment provides some evidence that the concentrations of nitrites where they observed NDMA are much higher than what might be expected in a normal diet.
aiphex 7y ago
There is a huge amount of ignorance in this thread right now. More people need to read the papers that have been out for 10 years on the issue of conversion of ranitidine to NDMA inside the body. The real issue is not tainted drugs or exposure to heat, it's processes in the body which are converting ranitidine to NDMA, which result in NDMA levels in the body increasing over 400 fold. Here's one https://academic.oup.com/carcin/article/37/6/625/1744630 https://academic.oup.com/carcin/article/37/6/625/1744630

endothrowho333 7y ago

Yes, it looks pretty obvious that V@lisure is running a scare campaign to boost traffic towards their services. I wonder if there's another play at hand here, though. Did they get in a spat with suppliers? Are they trying to dump the price of ranitidine and nizatidine to buy up at markedly reduced value? Perhaps drive down demand from drugs with less margins towards higher ones? For those downvoting: this is business as usual in entrenched markets like pharmaceuticals -- especially since the FDA has no capacity to enforce anything. And on more thorough review, it looks like the hysteria has spread to many other countries as well -- how quaint. For those that really aren't aware of what good hysteria marketing looks like, please take a look at: https://www.valisure.com/blog/uncategorized/detection-of-ndma-in-raniditine/ https://www.valisure.com/blog/uncategorized/detection-of-ndm... Anyone that works in the world of marketing/PR can see it plainly. I don't feel like digging into what strings they had to pull in order to get this viral, but anyone possessed by curiosity should take a look at their team: https://www.valisure.com/about-us/ https://www.valisure.com/about-us/ After reading their profiles, two members should instantly pop out at you.

deeceejhay 7y ago
Which two members' profiles? I didn't immediately see something.
- endothrowho333 7y ago
  Cunningham and Gortler top out at MVPs -- if you base off their bios alone. Jirstrand is runner-up from all the impressive PR work she's done. Berkal: very weak maybe.

victor9000 7y ago

> Valisure also conducted tests with simulated gastric fluid (at body temperature, 37 degrees Celsius) and added sodium nitrite, simulating a diet with high levels of the common preservative found in processed meats, and found high levels of NDMA

endothrowho333 7y ago
See page 7: https://www.valisure.com/wp-content/uploads/Valisure-Ranitidine-FDA-Citizen-Petition-v4.12.pdf https://www.valisure.com/wp-content/uploads/Valisure-Ranitid... They did NOT simulate a normal diet with common levels of sodium nitrate. At 10 mM there is no NDMA found. Sodium nitrate concentrations for meat are much lower than 10 mM. The FDA puts a strict upper limit of sodium nitrate concentrations in meat at 100mg/kg, so around a concentration of .015mM (!) I don't need to do any further math to tell you no one is eating that much cured meat in a single sitting (it's simply not possible).
CrazyStat 7y ago
Not very helpful with knowing how much sodium nitrite they added. Are they simulating the diet of someone who eats a bologna sandwich for lunch every day, or the diet of someone who eats nothing but twenty pounds of straight bologna every day? Edit: sibling comment provides some evidence that the concentrations of nitrites where they observed NDMA are much higher than what might be expected in a normal diet.

aiphex 7y ago

There is a huge amount of ignorance in this thread right now. More people need to read the papers that have been out for 10 years on the issue of conversion of ranitidine to NDMA inside the body. The real issue is not tainted drugs or exposure to heat, it's processes in the body which are converting ranitidine to NDMA, which result in NDMA levels in the body increasing over 400 fold. Here's one https://academic.oup.com/carcin/article/37/6/625/1744630 https://academic.oup.com/carcin/article/37/6/625/1744630